|
Abnormal behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Whole mount in situ hybridization of pax2a and bcl2l11 genes revealed that their differential expression in the brain and skeleton were related to the corresponding phenotypic behavioral abnormality.
|
29874755 |
2018 |
|
Acute lymphocytic leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These observations suggest that an association of a deletion polymorphism of BIM and the response to induction therapy in BCP-ALL may be clinically minimal.
|
28641145 |
2017 |
|
Acute lymphocytic leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, we used zinc finger nucleases to generate ALL cell lines with the BIM deletion, and confirmed the ability of the deletion to mediate GC resistance in vitro.
|
25090024 |
2014 |
|
Acute lymphocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally.
|
30537507 |
2018 |
|
Acute lymphocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Hence, our results provide novel insight into the mechanism of apoptosis upon oncogene inactivation and suggest that induction of BIM-mediated apoptosis may be an important therapeutic approach for ALL.
|
27095570 |
2016 |
|
Acute lymphocytic leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We investigated Bim gene polymorphisms and their association with childhood ALL outcome, and the mechanism underlying the observed finding.
|
23908358 |
2013 |
|
Acute monocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts.
|
27144333 |
2016 |
|
Acute monocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM.
|
31756944 |
2019 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
It was showed that pro-apoptosis factor BIM participates in regulating tumor cell apoptosis under ischemia or hypoxia condition, while its role in CM apoptosis after AMI is still unclear.
|
28742197 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.
|
17927446 |
2007 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In EGFR-mutant lung adenocarcinoma cell lines with high BIM expression, concomitant high mTOR expression increased IC50 of gefitinib for cell proliferation.
|
26639561 |
2015 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our results indicate that the BIM deletion polymorphism might be a promising germline biomarker for gefitinib treatment in Chinese patients with lung adenocarcinoma.
|
29580739 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Thus, PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma was associated with BIM and VEGFA mRNA expression and with shorter PFS after gefitinib therapy.
|
29767258 |
2018 |
|
Adenocarcinoma of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
The differential expressions of IGF-1R, FOXO3A, and BIM in the benign versus malignant prostate tissues supported a negative association between the FOXO3A/BIM axis and IGF-1R expression in human prostate adenocarcinoma.
|
31312023 |
2019 |
|
Adenoma
|
0.040 |
Biomarker
|
group |
BEFREE |
BIM-23A760 effects were similar to those induced by the selective D2R agonist cabergoline that showed a statistically significant inhibition in 18 out of 27 tumors (compared with a significant inhibition obtained in 17 out of 27 tumors using BIM-23A760, in the same subgroup of adenomas analyzed), while octreotide was effective in 13 out of 27 cases.
|
18509006 |
2008 |
|
Adenoma
|
0.040 |
Biomarker
|
group |
BEFREE |
BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas.
|
28181484 |
2017 |
|
Adenoma
|
0.040 |
Biomarker
|
group |
BEFREE |
BIM-23244 reduced PRL secretion only in adenomas expressing sst2, sst5 and DR2. sst5 and DR2 expression correlated directly with BIM23206 inhibitory effects on PRL secretion.
|
16216913 |
2005 |
|
Adenoma
|
0.040 |
Biomarker
|
group |
BEFREE |
Our studies identify Bim as a critical mediator of TGF-β-induced apoptosis in intestinal adenomas and show that the common progression mutations modify Bim levels and sensitivity to TGF-β during intestinal adenoma development.
|
24825889 |
2014 |
|
Adenomatous Polyposis Coli
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This recruitment of BIM is enhanced in cells lacking APC.
|
22399804 |
2012 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These observations suggest that an association of a deletion polymorphism of BIM and the response to induction therapy in BCP-ALL may be clinically minimal.
|
28641145 |
2017 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Hence, our results provide novel insight into the mechanism of apoptosis upon oncogene inactivation and suggest that induction of BIM-mediated apoptosis may be an important therapeutic approach for ALL.
|
27095570 |
2016 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We investigated Bim gene polymorphisms and their association with childhood ALL outcome, and the mechanism underlying the observed finding.
|
23908358 |
2013 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, we used zinc finger nucleases to generate ALL cell lines with the BIM deletion, and confirmed the ability of the deletion to mediate GC resistance in vitro.
|
25090024 |
2014 |
|
Adult Anaplastic Large Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex.
|
23633923 |
2013 |
|
Adult Burkitt Lymphoma
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
Thus, the P53-inducible PIG7/LITAF was silenced by homozygous deletion in primary mediastinal B-cell lymphoma and by promoter hypermethylation in germinal center lymphoma, the proapoptotic BIM gene presented homozygous deletion in mantle cell lymphoma and promoter hypermethylation in Burkitt lymphoma, the proapoptotic BH3-only NOXA was mutated and preferentially silenced in diffuse large B-cell lymphoma, and INK4c/P18 was silenced by biallelic mutation in mantle-cell lymphoma.
|
16960149 |
2007 |