|
Adenocarcinoma of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
The differential expressions of IGF-1R, FOXO3A, and BIM in the benign versus malignant prostate tissues supported a negative association between the FOXO3A/BIM axis and IGF-1R expression in human prostate adenocarcinoma.
|
31312023 |
2019 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data defined LINC00261/miR-132-3p/BCL2L11 regulatory networks may be a novel therapeutic target for endometriosis.
|
31105834 |
2019 |
|
HIV Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we show that upon HIV infection, macrophages increase the expression of BCL2, BCLXL, TREM1, mitofusin 1 (MFN1), and MFN2 and the translocation of BCL2L11 (BIM) to the mitochondria and decrease the expression of BCL2-associated agonist of cell death (BAD) and BAX while maintaining a 95% survival rate over 28 days.
|
31719184 |
2019 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accumulating pre-clinical evidence shows that miR-124 may act through calpain 1/p25/cyclin-dependent kinases 5 (CDK5), nuclear factor-kappa B (NF-κB), signal transducer and activator of transcription 3 (STAT3), Bcl-2-interacting mediator of cell death (Bim), 5' adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-regulated kinase (ERK)-mediated pathways to regulate cell survival, apoptosis, autophagy, mitochondrial dysfunction, oxidative damage and neuroinflammation in PD.
|
31707035 |
2019 |
|
Prune Belly Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results were further verified in metastatic PHEO, where the intratumoral injections of mannan-BAM, toll-like receptor ligands, and anti-CD40 into subcutaneous tumors resulted in significantly less intense bioluminescence signals of liver metastatic lesions induced by tail vein injection compared to the PBS-treated group.
|
31083581 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The proapoptotic effect of copanlisib was associated with DLBCL subtype-specific dysregulated expression of BCL-2 family members including harakiri (HRK) and its antiapoptotic partner BCL extra large (BCL-xL), BCL2 related protein A1, myeloid cell leukemia 1 (MCL-1), and BCL2 interacting mediator of cell death.
|
30322870 |
2019 |
|
Malignant Bone Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
MrgC agonist bovine adrenal medulla 8-22 (BAM 8-22) or MrgC antagonist anti-MrgC antibody were injected intrathecally on day 14 after bone cancer pain was successfully induced.
|
31515677 |
2019 |
|
secondary acute myeloid leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Durable remissions with venetoclax monotherapy in secondary AML refractory to hypomethylating agents and high expression of BCL-2 and/or BIM.
|
30725494 |
2019 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To sum up, these data suggests HAND2-AS1 as an anti-oncogene in OC through upregulation of BCL2L11 by competitively binding to miR-340-5p, which demonstrates that there are potential diagnosis and therapy values of HAND2-AS1 in OC.
|
31222748 |
2019 |
|
Estrogen receptor positive tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All the tested compounds affected estrogen receptor-positive tumor (MCF-7) cell growth, even with different extents, among which, the most active ones proved also to induce mitochondria-mediated apoptosis through activation of PARP cleavage, decrease in Bax/Bcl-2 ratio and increase in Bim gene expression levels.
|
30782572 |
2019 |
|
Painful Bladder Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results were further verified in metastatic PHEO, where the intratumoral injections of mannan-BAM, toll-like receptor ligands, and anti-CD40 into subcutaneous tumors resulted in significantly less intense bioluminescence signals of liver metastatic lesions induced by tail vein injection compared to the PBS-treated group.
|
31083581 |
2019 |
|
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
BIM autoantibody is a promising MPE biomarker by high-throughput autoantibody analysis in MPE and TPE.
|
31567996 |
2019 |
|
Multiple Chronic Conditions
|
0.010 |
Biomarker
|
disease |
BEFREE |
elPrep is an established multi-threaded framework for preparing SAM and BAM files in sequencing pipelines.
|
31159721 |
2019 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.
|
30518879 |
2018 |
|
Dehydration
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
BAM receptors are required for the CLE25 peptide-induced dehydration stress response in leaves, and the CLE25-BAM module therefore probably functions as one of the signalling molecules for long-distance signalling in the dehydration response.
|
29618812 |
2018 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this review, we describe the apoptotic mechanisms mediated by BIM activation in β cells in obesity and both forms of diabetes.
|
30036494 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
In this review, we describe the apoptotic mechanisms mediated by BIM activation in β cells in obesity and both forms of diabetes.
|
30036494 |
2018 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we demonstrate that FGFR therapy primes SqCC for cell death by increasing the expression of the pro-apoptotic protein BIM.
|
29743589 |
2018 |
|
Malnutrition
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we show that the CLAVATA3/EMBRYO-SURROUNDING REGION-RELATED 25 (CLE25) peptide transmits water-deficiency signals through vascular tissues in Arabidopsis, and affects abscisic acid biosynthesis and stomatal control of transpiration in association with BARELY ANY MERISTEM (BAM) receptors in leaves.
|
29618812 |
2018 |
|
Abnormal behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Whole mount in situ hybridization of pax2a and bcl2l11 genes revealed that their differential expression in the brain and skeleton were related to the corresponding phenotypic behavioral abnormality.
|
29874755 |
2018 |
|
Chronic Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This pathway, involving pAKT1, pFOXO1, FOXP3, IDO1 and BIM, is activated in humans with CP and in mice orally infected with Mfa1 expressing P. gingivalis strains.
|
30413788 |
2018 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the role of an important cell apoptosis initiator, Bcl-2 interacting mediator of cell death (Bim), by evaluating its expression and association with other clinicopathological features in ICCs.
|
29698699 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High Bim expression was also correlated with low Ki-67 index, and more importantly, none of the tumors with high Bim expression had lymph node metastases at the time of surgery.
|
29698699 |
2018 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.
|
30518879 |
2018 |
|
Ameloblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
On the basis of our results, the transcription of the apoptosis-related gene BCL2L11 is possibly regulated by promoter DNA methylation in ameloblastoma.
|
28248452 |
2017 |