|
Autosomal Recessive Polycystic Kidney Disease
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Taken together, our findings suggest that miR-1225-5p functions as a tumor suppressor in osteosarcoma by targeting Sox9, thereby revealing new therapeutic targets for osteosarcoma.
|
31765229 |
2020 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B.
|
30138106 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of miR-1225-5p significantly inhibited TPC-1 cell proliferation, increased cell apoptosis, and suppressed migration and invasion.
|
31288899 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
MicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1.
|
30319274 |
2018 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Through establishing a miR-1225-5p overexpression glioblastoma cell line, we found that ectopic overexpression of miR-1225-5p inhibited the proliferation, migration, and invasion of glioblastoma cells in vitro.
|
30319274 |
2018 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Functional assays demonstrated that ectopic overexpression of miR-1225-5p could inhibit cell proliferation, colony formation, migration and invasion in vitro, as well as suppress tumor growth and metastasis in nude mice.
|
26684358 |
2016 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Differential expression of miR-21, miR-320c, and miR-1225-5p was validated in the PLF of serosa-invasive and non-invasive GC by qRT-PCR and miR-21 and miR-1225-5p were confirmed to be associated with serosal invasion in GC.
|
26208314 |
2015 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
MicroRNA expression patterns differ between various sporadic, hereditary and recurring tumors and miR-1225-3p may be useful for identifying recurring pheochromocytomas.
|
20818339 |
2010 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Our data reveal that downregulation of miR-1225-5p may promote tumor cell proliferation and metastasis in thyroid cancer <i>via</i> a direct targeting of SIRT3.
|
31288899 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Functional assays demonstrated that ectopic overexpression of miR-1225-5p could inhibit cell proliferation, colony formation, migration and invasion in vitro, as well as suppress tumor growth and metastasis in nude mice.
|
26684358 |
2016 |
|
Stomach Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Therefore, downregulation of miR-1225-5p is likely to be one of major molecular mechanisms accounting for the development and progression of GC.
|
26684358 |
2016 |
|
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Differential expression of miR-21, miR-320c, and miR-1225-5p was validated in the PLF of serosa-invasive and non-invasive GC by qRT-PCR and miR-21 and miR-1225-5p were confirmed to be associated with serosal invasion in GC.
|
26208314 |
2015 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To elucidate the mechanism by which miR-1225-5p inhibits the development of osteosarcoma, we identified Sox9 as a target gene of miR-1225-5p using the TargetScan website.
|
31765229 |
2020 |
|
Osteosarcoma recurrent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using GSE39040, we found that low miR-1225-5p expression is associated with poor prognosis in patients with osteosarcoma, and we also found low miR-1225-5p expression in patients with recurrent osteosarcoma.
|
31765229 |
2020 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
To elucidate the mechanism by which miR-1225-5p inhibits the development of osteosarcoma, we identified Sox9 as a target gene of miR-1225-5p using the TargetScan website.
|
31765229 |
2020 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To elucidate the mechanism by which miR-1225-5p inhibits the development of osteosarcoma, we identified Sox9 as a target gene of miR-1225-5p using the TargetScan website.
|
31765229 |
2020 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
SIGNIFICANCE OF THE STUDY: Our study showed that miR-1225 is significant in multiple malignancies and other pathological reactions.
|
31017694 |
2019 |
|
Malignant neoplasm of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B.
|
30138106 |
2019 |
|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The miR-1225-5p expression in thyroid cancer tissue and cell lines was detected, followed by detecting the effects of overexpression of miR-1225-5p on the proliferation, apoptosis, migration and invasion of thyroid cancer cells.
|
31288899 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The miR-1225-5p expression in thyroid cancer tissue and cell lines was detected, followed by detecting the effects of overexpression of miR-1225-5p on the proliferation, apoptosis, migration and invasion of thyroid cancer cells.
|
31288899 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
EdU staining demonstrated that the aberrant expression of miR-1225 impaired the proliferation and survival of these two PC cell lines.
|
30990343 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
EdU staining demonstrated that the aberrant expression of miR-1225 impaired the proliferation and survival of these two PC cell lines.
|
30990343 |
2019 |
|
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The miR-1225-5p expression in thyroid cancer tissue and cell lines was detected, followed by detecting the effects of overexpression of miR-1225-5p on the proliferation, apoptosis, migration and invasion of thyroid cancer cells.
|
31288899 |
2019 |
|
Carcinoma of larynx
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that the expression of miR-1225 was suppressed in human LC samples, while CDC14B (cell division cycle 14B) expression was reinforced in comparison with surrounding normal tissues.
|
30138106 |
2019 |