SH2B3, SH2B adaptor protein 3, 10019

N. diseases: 212; N. variants: 21
Disease: Coronary heart disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease BEFREE The goal of our study is to evaluate the association between the R262W polymorphism of SH2B3 gene and risk of CHD. 30508957 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease BEFREE However, the mechanisms underlying the association of LNK single-nucleotide polymorphisms with coronary heart disease are poorly understood. 27430239 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease GWASCAT Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325 2014
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease BEFREE In conclusion, our results supported a significant association between rs3184504 of SH2B3 gene and the risk of CHD in Europeans and South Asians, although we were unable to observe association between the four variants and the risk of CHD in Han Chinese. 23328882 2013
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease BEFREE The one exception was rs653178 near SH2B3 (SH2B adaptor protein 3), which showed direction-consistent association with systolic (P = 9.3 ×10(-10)) and diastolic (P = 1.6 ×10(-14)) blood pressure and coronary artery disease (P = 2.2 ×10(-6)), all previously reported. 23474010 2013
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011