DUX4, double homeobox 4, 100288687

N. diseases: 79; N. variants: 0
Disease: Leukemia, B-Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2004493
Disease: Leukemia, B-Cell
Leukemia, B-Cell 		0.020 AlteredExpression disease BEFREE DUX4 regulates expression of repetitive elements during early embryogenesis, but misexpression of DUX4 causes facioscapulohumeral muscular dystrophy (FSHD) and translocations overexpressing the DUX4 double homeodomain cause B cell leukemia. 30540931 2018
CUI: C2004493
Disease: Leukemia, B-Cell
Leukemia, B-Cell 		0.020 AlteredExpression disease BEFREE A transplantation assay in mice demonstrated that expression of DUX4-IGH in pro-B cells was capable of generating B cell leukemia in vivo. 27019113 2016