Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE We replicated the effect of a new locus detected in the Japanese cohort (PARK16, rs823128, OR = 0.66, P = 7.29 x 10(-8)) and provide supporting evidence that common variation around LRRK2 modulates risk for PD (rs1491923, OR = 1.14, P = 1.55 x 10(-5)). 19915575 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 Biomarker disease CTD_human By comparing results of a GWAS performed on individuals of European ancestry, we identified PARK16, SNCA and LRRK2 as shared risk loci for PD and BST1 and MAPT as loci showing population differences. 19915576 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 Biomarker disease CTD_human We replicated the effect of a new locus detected in the Japanese cohort (PARK16, rs823128, OR = 0.66, P = 7.29 x 10(-8)) and provide supporting evidence that common variation around LRRK2 modulates risk for PD (rs1491923, OR = 1.14, P = 1.55 x 10(-5)). 19915575 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE By comparing results of a GWAS performed on individuals of European ancestry, we identified PARK16, SNCA and LRRK2 as shared risk loci for PD and BST1 and MAPT as loci showing population differences. 19915576 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE There was a trend toward a stronger protective effect of SNPs at the PARK16 locus in sporadic PD compared to familial cases and in older compared to younger subjects. 20697102 2010
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE The majority of studies have confirmed the association of the previously identified genetic risk factors, SNCA and MAPT, and two studies have identified three new PD susceptibility loci/genes (PARK16, BST1 and HLA-DRB5). 21812969 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Our findings suggest that additional studies of PARK16-18 are necessary to establish the role of these loci in modifying risk for Parkinson's disease in European-derived populations.© 2011 Movement Disorder Society. 21425343 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE We showed that multiple SNPs at LRRK2 and SNCA increase risk of PD, while PARK16 SNPs are associated with a lower risk of PD in China. 21268244 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Using a dataset of post-mortem brain samples assayed for gene expression (n = 399) and methylation (n = 292), we identified methylation and expression changes associated with PD risk variants in PARK16/1q32, GPNMB/7p15, and STX1B/16p11 loci, hence suggesting potential molecular mechanisms and candidate genes at these risk loci. 21738488 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE An association between the PARK16 locus and Parkinson's disease in a cohort from eastern China. 21840748 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Further analysis is required to determine the role of genes within the PARK16 locus in development of PD. 21812739 2011
CUI: C0026650
Disease: Movement Disorders
Movement Disorders 		0.010 GeneticVariation group BEFREE Our findings suggest that additional studies of PARK16-18 are necessary to establish the role of these loci in modifying risk for Parkinson's disease in European-derived populations.© 2011 Movement Disorder Society. 21425343 2011
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.010 GeneticVariation disease BEFREE We performed direct DNA sequencing of the RAB7L1 and SLC41A1 genes within the PARK16 locus in 205 Chinese Parkinson's disease (PD) patients. 21812739 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Our data demonstrate that specific SNP variations and haplotypes in the PARK16 locus are associated with reduced risk for PD in Ashkenazim. 22232350 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Here we show that the consequences of variants at 2 such loci, PARK16 and LRRK2, are highly interrelated, both in terms of their broad impacts on human brain transcriptomes of unaffected carriers, and in terms of their associations with PD risk. 23395371 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE In a logistic regression analysis with SNPs coded under an additive model, there was no significant genetic interaction between the LRRK2 and the PARK16 locus gene RAB7L1 in PD risk. 23820587 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Interestingly, gene SLC41A1 located in the novel PD locus PARK16 has recently been identified as being a Na⁺/Mg²⁺ exchanger (NME, Mg²⁺ efflux system), a key component of cellular magnesium homeostasis. 23976986 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Herein, we investigated the effect of 4 single-nucleotide polymorphisms (SNPs) within the PARK16 locus, including rs823128, rs947211, rs823156, and rs11240572, on the risk of PD by genotyping 497 Taiwanese patients with PD and 500 age-matched control subjects. 23747047 2013
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 Biomarker disease BEFREE Our results confirm the associations of SNCA, LRRK2, BST1, and PARK16 with PD susceptibility and fail to show significant associations of AD genome-wide association study (GWAS) top hits with PD susceptibility in a Korean population. 23820587 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Our data provide a novel insight and further information regarding PARK16-18 loci in PD susceptibility. 24373818 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Association between PARK16 gene polymorphisms and susceptibility of Parkinson's disease in a Chinese population. 25966061 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE The PARK16 locus was reported to alter the risk of Parkinson's disease (PD) in genomewide association studies in Japanese and Caucasians. 25758099 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 Biomarker disease BEFREE In the present study, we aimed to explore the contribution of PARK16 variability to PD risk in a Scandinavian population. 25855069 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Sequence variants in SLC41A1 (solute carrier family 41 member 1) within the PARK16 locus have been reported to be associated with Parkinson's disease (PD). 26308152 2015
CUI: C4511452
Disease: Sporadic Parkinson disease
Sporadic Parkinson disease 		0.030 GeneticVariation disease BEFREE We also validated 2 new single-nucleotide polymorphisms, rs947211 and rs823144, in PARK16 to explore their association with susceptibility to PD in the Xinjiang Uygur and Han populations. 25966061 2015