|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results confirm the associations of SNCA, LRRK2, BST1, and PARK16 with PD susceptibility and fail to show significant associations of AD genome-wide association study (GWAS) top hits with PD susceptibility in a Korean population.
|
23820587 |
2013 |
|
Movement Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our findings suggest that additional studies of PARK16-18 are necessary to establish the role of these loci in modifying risk for Parkinson's disease in European-derived populations.© 2011 Movement Disorder Society.
|
21425343 |
2011 |
|
PARKINSON DISEASE, LATE-ONSET
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We performed direct DNA sequencing of the RAB7L1 and SLC41A1 genes within the PARK16 locus in 205 Chinese Parkinson's disease (PD) patients.
|
21812739 |
2011 |
|
Sporadic Parkinson disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Many genetic variants have been linked to familial or sporadic Parkinson's disease (PD), among which those identified in PARK16, BST1, SNCA, LRRK2, GBA and MAPT genes have been demonstrated to be the most common risk factors worldwide.
|
27299523 |
2016 |
|
Sporadic Parkinson disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson's disease in Japan.
|
26944116 |
2016 |
|
Sporadic Parkinson disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We also validated 2 new single-nucleotide polymorphisms, rs947211 and rs823144, in PARK16 to explore their association with susceptibility to PD in the Xinjiang Uygur and Han populations.
|
25966061 |
2015 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a 9-year longitudinal study, we demonstrated that PD PARK16 variant carriers exhibited greater motor progression after 5 years of disease compared with non-carriers, suggesting that GWAS-linked gene variants may influence disease progression over time.
|
30814270 |
2019 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Within its limitations, this meta-analysis demonstrated that the rs823128 variants(G allele, GA and GG genotype)in PARK16 might be a potential protective factor for PD.
|
29191693 |
2018 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.
|
27814993 |
2017 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association between PARK16 and Parkinson's disease: A meta-analysis.
|
28807727 |
2017 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the epidemiological evidence on the relationships between PARK16 single-nucleotide polymorphisms (rs823128, rs1572931, and rs823156) and PD is inconsistent.
|
28749816 |
2017 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, ADORA1 is located within the Parkinson's disease locus PARK16, which has been identified in several populations.
|
27134041 |
2016 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PARK16 was identified as a risk factor for Parkinson's disease in a Japanese cohort; however, subsequent studies in the other populations including the Chinese, European, Caucasian, and Chilean have shown a protective role instead.
|
27174169 |
2016 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The PARK16 SNPs rs823128, rs947211, and rs823156 and the CAAAC, TGAGA, and CAGAC haplotypes may be significantly associated with sporadic PD in Japan.
|
26944116 |
2016 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between PARK16 gene polymorphisms and susceptibility of Parkinson's disease in a Chinese population.
|
25966061 |
2015 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The PARK16 locus was reported to alter the risk of Parkinson's disease (PD) in genomewide association studies in Japanese and Caucasians.
|
25758099 |
2015 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we aimed to explore the contribution of PARK16 variability to PD risk in a Scandinavian population.
|
25855069 |
2015 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sequence variants in SLC41A1 (solute carrier family 41 member 1) within the PARK16 locus have been reported to be associated with Parkinson's disease (PD).
|
26308152 |
2015 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data provide a novel insight and further information regarding PARK16-18 loci in PD susceptibility.
|
24373818 |
2014 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we show that the consequences of variants at 2 such loci, PARK16 and LRRK2, are highly interrelated, both in terms of their broad impacts on human brain transcriptomes of unaffected carriers, and in terms of their associations with PD risk.
|
23395371 |
2013 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a logistic regression analysis with SNPs coded under an additive model, there was no significant genetic interaction between the LRRK2 and the PARK16 locus gene RAB7L1 in PD risk.
|
23820587 |
2013 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, gene SLC41A1 located in the novel PD locus PARK16 has recently been identified as being a Na⁺/Mg²⁺ exchanger (NME, Mg²⁺ efflux system), a key component of cellular magnesium homeostasis.
|
23976986 |
2013 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Herein, we investigated the effect of 4 single-nucleotide polymorphisms (SNPs) within the PARK16 locus, including rs823128, rs947211, rs823156, and rs11240572, on the risk of PD by genotyping 497 Taiwanese patients with PD and 500 age-matched control subjects.
|
23747047 |
2013 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrate that specific SNP variations and haplotypes in the PARK16 locus are associated with reduced risk for PD in Ashkenazim.
|
22232350 |
2012 |
|
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The majority of studies have confirmed the association of the previously identified genetic risk factors, SNCA and MAPT, and two studies have identified three new PD susceptibility loci/genes (PARK16, BST1 and HLA-DRB5).
|
21812969 |
2011 |