PARP2, poly(ADP-ribose) polymerase 2, 10038

N. diseases: 40; N. variants: 2
Disease: Hepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.010 AlteredExpression group BEFREE In conclusion, our results suggest that the defect of T-lymphocyte maturation in <i>Parp2</i> knockout mice leads to a systemic reduction of iNKT cells, reducing hepatocyte death during ConA-mediated liver damage, thus protecting the mice from hepatitis.<b>NEW & NOTEWORTHY</b> The genetic inactivation of Parp2, but not Parp1, protects mice from concanavalin A hepatitis. 28751426 2017