Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated pain sensitivity in humans with WAGR (Wilms tumor, aniridia, genitourinary anomaly, and range of intellectual disabilities) syndrome, who have variably sized heterozygous deletion of the 11p13 region.
|
30855519 |
2019 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our previous study of congenital aniridia patients revealed a noticeable number of aniridia patients with WAGR-region deletions but without Wilms' tumor in their medical history.
|
31304537 |
2019 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interstitial deletions of the 11p13 region are known to cause WAGR (Wilms tumor, aniridia, genitourinary malformation, and "mental retardation") syndrome, a contiguous gene deletion syndrome due to haploinsufficiencies of the genes in this region, including WT1 and PAX6.
|
24357251 |
2014 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The WAGR contiguous gene deletion syndrome is a combination of Wilms tumor, aniridia, genito-urinary abnormalities, and mental retardation.
|
21660403 |
2011 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
WAGR (Wilms tumor, Aniridia, Genitourinary malformations and mental Retardation) syndrome is a rare genomic disorder caused by deletion of the 11p14-p12 chromosome region.
|
19096215 |
2008 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
These include WAGR (for Wilms tumor, aniridia, genitourinary anomalies, and mental retardation), and Frasier and Denys-Drash syndromes.
|
18385267 |
2008 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The WAGR contiguous gene deletion syndrome is a combination of Wilms tumor, aniridia, genitourinary abnormalities, and mental retardation.
|
17935232 |
2007 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aniridia and predisposition for Wilms tumor seen in WAGR are caused by haploinsufficiency for PAX 6 and WT1, respectively.
|
16646034 |
2006 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The WAGR contiguous gene deletion syndrome is a combination of Wilms tumor, Aniridia, Genito-urinary abnormalities, and growth and mental retardation which is invariably associated with an 11p13 deletion.
|
15779023 |
2005 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the WT1 gene were identified in patients with WAGR (Wilms' tumor, aniridria, genitourinary abnormalities, and mental retardation), Denys-Drash syndrome, and Frasier syndrome (FS).
|
12050205 |
2002 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The remaining four had chromosomal rearrangements: an unbalanced translocation, t(11;13), with a deletion including the WAGR (Wilms' tumor, aniridia, genitourinary abnormalities, and mental retardation) region, and three balanced rearrangements with what appear to be position effect breakpoints 3' of PAX6: (a) a t(7;11) with the 11p13 breakpoint approximately 30 kb downstream of PAX6, (b) a dir ins(12;11) with a breakpoint >50 kb from PAX6, and (c) an inv(11)(p13q13) with a breakpoint >75 kb downstream of PAX6.
|
12386836 |
2002 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genital abnormalities associated with Wilms' tumors in the WAGR and Denys-Drash syndromes and the failure of the gonads to develop in Wilms' tumor gene (wt1)-homozygous mutant mice suggest that WT1 may also function in sexual development.
|
9815658 |
1997 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two eSTS markers have been further mapped with respect to a yeast artificial chromosome (YAC) contig close to the brain-derived neurotrophic factor (BDNF) gene and thus provide potential candidate genes for the mental retardation phenotype of WAGR (Wilms' tumor, aniridia, genitourinary abnormalities and mental retardation) syndrome.
|
8717056 |
1995 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
WAGR (Wilms tumor, aniridia, genito-urinary abnormalities, mental retardation) syndrome in humans is associated with deletions of the 11p13 region.
|
7896291 |
1994 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor.
|
8402654 |
1993 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) with biotin-labeled probes mapping to 11p13 has been used for the molecular analysis of deletions of the WAGR (Wilms tumor, aniridia, genitourinary abnormalities, and mental retardation) locus.
|
1334370 |
1992 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene.
|
2154334 |
1990 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The WAGR (Wilms tumor, aniridia, genitourinary anomalies, and mental retardation) region has been assigned to chromosome 11p13 on the basis of overlapping constitutional deletions found in affected individuals.
|
2539014 |
1989 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All four del(11)(p13) cases presented with WAGR, a complex syndrome associated with a predisposition to Wilms' tumor (WT), aniridia (A), genitourinary abnormalities (G), and mental retardation (R).
|
2570677 |
1989 |
Childhood Kidney Wilms Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report the cytogenetic findings observed in the cancer cells of a Wilms' tumor in a 11-month-old girl without the phenotype of the WAGR.
|
2550862 |
1989 |
Childhood Kidney Wilms Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nine of these clones map to 11p13, and four of the nine [57(D11S89), 530(D11S90), 706(D11S93), and 1104(D11S95)] are confined to the same segment within p13 that contains catalase (CAT), the beta subunit of follicle stimulating hormone (FSHB), and the Wilms' tumor-aniridia (WAGR) gene complex.
|
2852164 |
1988 |