KLRC4-KLRK1, KLRC4-KLRK1 readthrough, 100528032

N. diseases: 246; N. variants: 5
Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.090 Biomarker disease BEFREE Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. 31316209 2019
CUI: C0023418
Disease: leukemia
leukemia 		0.090 Biomarker disease BEFREE Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. 31367045 2019
CUI: C0023418
Disease: leukemia
leukemia 		0.090 Biomarker disease BEFREE Still more targets such as CLL-1, EGFR, NKG2D and mesothelin are being directed in CAR-T cell trials for leukemia and solid tumors. 31703740 2019
CUI: C0023418
Disease: leukemia
leukemia 		0.090 Biomarker disease BEFREE Thus, NKG2D-Fc-ADCC potently enhances NK antileukemia reactivity despite the inevitable reduction of activating signals upon binding to NKG2DL and may constitute an attractive means for immunotherapy of leukemia. 25046567 2015
CUI: C0023418
Disease: leukemia
leukemia 		0.090 AlteredExpression disease BEFREE Together, we provide comprehensive data on the relevance of NKG2D/NKG2DL expression, release, and function for NK reactivity in leukemia, which exemplifies the mechanisms underlying NKG2D-mediated tumor immunosurveillance and escape. 22730533 2012
CUI: C0023418
Disease: leukemia
leukemia 		0.090 Biomarker disease BEFREE Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate. 19151770 2009
CUI: C0023418
Disease: leukemia
leukemia 		0.090 AlteredExpression disease BEFREE In this study, we investigated the effects of IL-18 on the expression of NKG2D ligands in leukemia cells. 18706445 2008
CUI: C0023418
Disease: leukemia
leukemia 		0.090 Biomarker disease BEFREE Here, we have studied the role of NKG2D and natural cytotoxicity receptors (NCRs) in the recognition of human leukemia. 15657183 2005
CUI: C0023418
Disease: leukemia
leukemia 		0.090 Biomarker disease BEFREE Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. 12714493 2003