|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
B-lymphoma Moloney murine leukemia virus insertion region-1 (BMI-1) was confirmed to be a direct target for miR-218 and upregulated in LA tissues, which indicated the poor prognosis of LA patients.
|
31599423 |
2019 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant higher expression of B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) has been reported in cell lines from metastatic melanoma compared to cell lines from primary melanoma.
|
27878257 |
2017 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The importance of B-lymphoma Moloney murine leukemia virus insertion region-1 (BMI-1) was implicated in cell proliferation, stem cell maintenance, and tumor initiation.
|
28270035 |
2017 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
BITC treatment resulted in a marked decrease in protein level of polycomb group protein B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) in cultured human breast cancer cells (MCF-7, SUM159, MDA-MB-231, and MDA-MB-361) and MDA-MB-231 xenografts in vivo.
|
25663545 |
2015 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Coexpression of Bmi-1 and Ezh2 is a characteristic of aggressive lymphomas.
|
23948956 |
2013 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Oncogenic Bmi-1 (B-lymphoma Moloney murine leukemia virus insertion region-1) belongs to the Polycomb-group (PcG) family of proteins and plays an important role in the regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription.
|
22994774 |
2012 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
BMI-1 could be an important prognostic marker as well as a future therapeutic target in the treatment of drug-resistant lymphomas.
|
21999765 |
2012 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) acts as an oncogene in various tumors, and its overexpression correlates with a poor outcome in several human cancers.
|
21276221 |
2011 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
However, overexpression of the PcG protein, Bmi-1, causes lymphoma in transgenic mice.
|
17148591 |
2007 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
BMI-1 is involved in the maintenance of stem cells and functions as an oncogene in both lymphomas and solid carcinomas, acting by downregulation of p16ink4a.
|
17244030 |
2007 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Silencing of p16/INK4A expression is frequently caused by hyper-methylation of CpG islands in its promoter but may also be achieved through activation of Bmi-1, for example in lymphomas associated with the E2A-Pbx1 translocation.
|
15611658 |
2005 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A good correlation between BMI-1 mRNA levels and protein expression was observed in all types of lymphomas.
|
11289106 |
2001 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In mice, downregulation of one of the polycomb genes, bmi-1, leads to neurological alterations and severe proliferative defects in lymphoid cells, whilst bmi-1 overexpression, together with upregulation of myc-1, induces lymphoma.
|
11355949 |
2001 |