|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
NFκBP65 transcription factor modulates resistance to doxorubicin through ABC transporters in breast cancer.
|
27878697 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Even nontoxic dose of Tan IIA could also promote intracellular Dox accumulation of MCF-7 and MCF-7/dox cells through down-regulating the expression of efflux ABC transporters including P-gp, BCRP and MRP1, which can effectively eliminated cancerous cells including BCSCs, thereby enhancing the chemosensitivity of breast cancer.
|
29028589 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated an enhancement effect of rhinacanthin-C on doxorubicin cytotoxicity in human breast cancer cell lines and the involvement of the ABC drug efflux transporters.
|
27916559 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since ABC transporters and their induction by chemotherapy drugs are a major cause of chemoresistance and treatment failure, these results support the idea that targeting the enzymatic activity of BRG1 would be an effective adjuvant therapy for breast cancer.
|
27029062 |
2016 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the effect of GNT on the expression and function of ABC transporters in MCF-7 and MDA-MB-231 breast cancer cell lines.
|
27033456 |
2016 |
|
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ABC successfully identifies previously characterized functional SNVs, such as the rs4784227 breast cancer risk associated SNP that modulates the affinity of FOXA1 for the chromatin.
|
25995231 |
2015 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the expression of ABC transporters P-glycoprotein (P-gp) and breast cancer related protein (BCRP) in non-neurologic controls, AD, and severe capillary cerebral amyloid angiopathy (capCAA) cases, which are characterized by deposition of Aβ within cerebral capillaries.
|
24138987 |
2014 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genotype frequencies of selected drug metabolizing enzymes and ABC drug transporters among breast cancer patients on FAC chemotherapy.
|
20102361 |
2010 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Discovered first in cancer, the activity of P-glycoprotein (P-gp) and others ABC transporters as multidrug-resistance-associated proteins (MRPs) and breast cancer resistant protein (BCRP) are directly related with the refractoriness.
|
17910594 |
2007 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We sequenced the HLA-A and HLA-B loci of eight commonly used prostate and breast cancer cell lines and analyzed the surface expression of HLA-ABC, HLA-DR, CD40, CD80, CD86, and CD54 by flow cytometry.
|
17219382 |
2007 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Iodinated oestradiol-labeled oestrogen receptor (ER) isoforms devoid of amino-terminal ABC domains represent about two-thirds of the whole receptor population detected in cytosol samples from human breast cancers.
|
11056692 |
2000 |
|
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
This review also focuses on drug resistance by ABC efflux transporters in cancer cells, particularly hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC) cells.
|
29303075 |
2019 |
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
ABC member B5 (ABCB5) mediates multidrug resistance (MDR) in diverse malignancies and confers clinically relevant 5-fluorouracil resistance to CD133-expressing cancer stem cells in human colorectal cancer (CRC).
|
29789423 |
2018 |
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
|
22294766 |
2012 |
|
Colorectal Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines.
|
12636175 |
2003 |
|
Dyschromatosis universalis
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mutations in ABCB6 cause dyschromatosis universalis hereditaria.
|
23519333 |
2013 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
|
22294766 |
2012 |
|
Coloboma of optic disc
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
ABCB6 mutations cause ocular coloboma.
|
22226084 |
2012 |
|
Congenital coloboma of iris
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
ABCB6 mutations cause ocular coloboma.
|
22226084 |
2012 |
|
Coloboma of lens
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
ABCB6 mutations cause ocular coloboma.
|
22226084 |
2012 |
|
Coloboma of eyelid
|
0.300 |
GermlineCausalMutation
|
phenotype |
ORPHANET |
ABCB6 mutations cause ocular coloboma.
|
22226084 |
2012 |
|
Hereditary macular coloboma
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
ABCB6 mutations cause ocular coloboma.
|
22226084 |
2012 |
|
Microphthalmia associated with colobomatous cyst
|
0.300 |
GermlineCausalMutation
|
phenotype |
ORPHANET |
ABCB6 mutations cause ocular coloboma.
|
22226084 |
2012 |
|
Coloboma of choroid and retina
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
ABCB6 mutations cause ocular coloboma.
|
22226084 |
2012 |