DNM1L, dynamin 1 like, 10059

N. diseases: 273; N. variants: 15
Disease: Diabetic Nephropathy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.030 Biomarker disease BEFREE Taken together, these findings establish that a single phosphorylation site in Drp1 can regulate mitochondrial fission and progression of DN in vivo, and highlight the stimulus-specific consequences of Drp1S600 phosphorylation on mitochondrial dynamics. 31063459 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.030 Biomarker disease BEFREE The AKAP1-Drp1 pathway may contribute to mitochondrial fission in the pathogenesis of DN. 31349216 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.030 Biomarker disease BEFREE These data suggest that PGC-1α may protect DN via the inhibition of DRP1-mediated mitochondrial dynamic remodeling and ROS production. 25853493 2015