|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, silibinin treatment increases mitochondrial fusion through down-regulating the expression of mitochondrial fission-associated protein dynamin-related protein 1 (DRP1) and up-regulating the expression of mitochondrial fusion-associated proteins, optic atrophy 1, mitofusin 1 and mitofusin 2.
|
31612353 |
2020 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, the mRNA and protein expression of dynamin-related protein 1 (Drp1), mitochondrial fission factor (Mff), mitofusin 1 and 2 (Mfn1 and Mfn2), optic atrophy 1 (Opa1) indicated imbalance between mitochondrial inner and outer membrane and results in mitochondrial dysfunction in broilers BF.
|
31841897 |
2020 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The skin wound area, blood perfusion, superoxide production, malondialdehyde (MDA) levels, total antioxidant capacity (T-AOC), expression of vascular endothelial growth factor (VEGF), dynamin-related protein 1 (DRP1) and optic atrophy 1 (OPA1) were measured.
|
30927279 |
2019 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, both HIIT and MICT interventions down-regulated dynamin-related protein 1 (DRP1) and fission 1 (FIS1), whereas mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1) were up-regulated.
|
31445975 |
2019 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Dose-dependent elevations in the levels of mitochondrial fission (Drp1 and Fis1) and fusion (Opa1, Mfn1, and Mfn2) proteins were observed.
|
31055771 |
2019 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further quantitative real-time PCR demonstrated that B cell lymphoma/leukemia 2 (Bcl2) were significantly decreased and dynamin-related protein 1 (Drp1), Optic atrophy 1 (Opa1), mitochondrial fission factor 1 (Mfn1), Mfn2, p53, caspase-8, Bcl-2 associated X protein (Bax), caspase-3, caspase-9 and cytochrome C were significantly increased in all As2O3 group.
|
30339249 |
2019 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mitochondrial fusion is primarily controlled by three GTPases, mitofusin 1 (Mfn1), Mfn2, and optic atrophy 1 (Opa1), while mitochondrial fission is primarily regulated by GTPase dynamin-related protein 1 (Drp1).
|
31551926 |
2019 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of mitochondrial fission-associated proteins including dynamin-related protein 1 (DRP1) is up-regulated, whereas expression of the mitochondrial fusion-associated proteins, optic atrophy 1 and mitofusin 1, is down-regulated.
|
31085166 |
2019 |
|
Optic Atrophy 1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The potential mechanism underlying the protective effect of Mdivi-1 involved Mdivi-1 reestablishing mitochondrial fusion-fission balance in sepsis, as reflected by the expression of the mitofusin 2 (MFN2) and optic atrophy 1 (OPA1) , Drp1 translocation, and mitochondrial morphology, as observed by electron microscopy.
|
31263382 |
2019 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of dynamin-related protein 1 (DRP1) and optic atrophy 1 (OPA1) in the mitochondria was measured by Western blot.
|
31030549 |
2019 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Indomethacin impaired mitochondrial dynamics by promoting fissogenic activation and mitochondrial recruitment of DRP1 and down-regulating fusogenic optic atrophy 1 (OPA1) and mitofusins in rat gastric mucosa.
|
30940726 |
2019 |
|
Optic Atrophy 1
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Mechanistically, lipid-induced changes in mitochondrial redox status increased mitochondrial fission by increased ubiquitination of AKAP121 (A-kinase anchor protein 121) leading to reduced phosphorylation of DRP1 (dynamin-related protein 1) at Ser637 and altered proteolytic processing of OPA1 (optic atrophy 1).
|
29092894 |
2018 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent advances revealed that a number of components of the fission and fusion machinery, including dynamin-related protein 1 (Drp1), mitofusin1/2 (Mfn1/2) and Optic atrophy 1 (OPA1), that have been implicated in mitochondrial shape changes are indispensible for autophagy, apoptosis and necroptosis.
|
30312515 |
2018 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus Mdivi-1 protected rats from SAE, and this protective effect could be associated with its inhibition of Drp1 and its activation of p-Drp1 and OPA1.
|
29395086 |
2018 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mitochondria form a dynamic network, balancing fusion, mediated by optic atrophy-1 (OPA1), and fission events, mediated by dynamin-related protein-1 (DRP1), to maintain homeostasis.
|
29961397 |
2018 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Optic atrophy 1 (OPA1) expression was upregulated, while dynamin-related protein 1 (DRP1) expression was downregulated.
|
30647820 |
2018 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we found that IR-783 induced dynamin-related protein 1 (Drp1) translocation from the cytosol to the mitochondria, increased the expression of mitochondrial fission proteins mitochondrial fission factor (MFF) and fission-1 (Fis1), and decreased the expression of mitochondrial fusion proteins mitofusin1 (Mfn1) and optic atrophy 1 (OPA1).
|
29993201 |
2018 |
|
Optic Atrophy 1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Knockdown of PGAM5 inhibited DRP1 translocation without a change in OPA1 expression in CCCP-treated cells.
|
29241732 |
2018 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that activation of the PKC-α/HO-1 signaling pathway increased superoxide dismutase activities and the respiratory control ratio (RCR), decreased the levels of malondialdehyde, reactive oxygen species (ROS), Drp1 and Fis1, and simultaneously enhanced the levels of Mfn1, Mfn2 and OPA1.
|
30112072 |
2018 |
|
Optic Atrophy 1
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Hyperoxic PECs exhibited increased phosphorylation of Drp-1 (serine 616), decreases in Mfn1 (mitofusion protein 1), but increases in OPA-1 (optic atrophy 1).
|
29419407 |
2018 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although mRNA levels of most markers of autophagy [PIK3C, MAP1LC3B, sequestosome 1 (SQSTM1), BCL-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3), BNIP3-like (BNIP3L)] and mitochondrial dynamics [optic atrophy 1 (OPA1), fission protein 1 (FIS1)] remained unchanged, some either increased during and after exercise (GABARAPL1), decreased in the recovery period [BECN1, autophagy-related (ATG) 7, DNM1L] or both [mitofusin (MFN) 2, mitochondrial E3 ubiquitin ligase 1 (MUL1)].
|
27837193 |
2017 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
OCR and the activity and OPA1 binding of CIV in isolated brain mitochondria from aged mice were restored by incubation with CoQ<sub>10</sub>, but not in the presence of 15-deoxy-prostaglandin J<sub>2</sub>, an inhibitor of a GTPase effector domain-containing GTPase such as OPA1 and DRP1.
|
28890359 |
2017 |
|
Optic Atrophy 1
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Isoproterenol not only caused cardiac injury but also increased the expression of mitochondrial fission proteins [dynamin-related peptide1 (Drp1) and mitochondrial fission protein1 (Fis-1)) and decreased the expression of fusion proteins (optic atrophy-1 (OPA1) and mitofusins1/2 (Mfn1/2)], thereby disrupting mitochondrial dynamics and leading to increase in mitochondrial fragments.
|
27491814 |
2017 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, trimetazidine improved mitochondrial biosynthesis and fission/fusion, as demonstrated by the promotion of peroxisome proliferator-activated receptor gamma (PPARγ) co-activator 1α (PGC-1α), mitofusins 1 (Mfn1), dynamin-related protein 1 (Drp1), and optic atrophy 1 (Opa1) expressions in rats with acute myocardial ischemia.
|
28761019 |
2017 |
|
Optic Atrophy 1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ssd is mediated via calcium signaling, up-regulation of the mitochondrial fission proteins Dynamin-related protein 1 (Drp1) and optic atrophy 1 (Opa1), and loss in mitochondrial membrane potential (MMP).
|
29245943 |
2017 |