SOD2 mRNA was downregulated, while LXRα gene expression was upregulated in DM<sup>+</sup>CAD<sup>-</sup>, DM<sup>+</sup>CAD<sup>+</sup>, and DM<sup>-</sup>CAD<sup>+</sup> groups compared to HS (<i>P</i> = 0.001, <i>P</i> = 0.03, and <i>P</i> = 0.001 for SOD2 and <i>P</i> = 0.006, <i>P</i> = 0.008, and <i>P</i> < 0.001 for LXRα, respectively).
One thousand five hundred seventy-four subjects of European ancestry with elevated risk for type 2 diabetes were genotyped for the two NR1H2 single nucleotide polymorphisms (SNPs) rs2248949 and rs1405655 and for the four NR1H3 SNPs rs11039149, rs3758673, rs12221497 and rs2279238, and association studies with metabolic traits were performed.
Eight common single nucleotide polymorphisms in LXRA and LXRB were analyzed for association with T2D in one French cohort (N = 988 cases and 941 controls), and for association with quantitative measures reflecting glucose homeostasis in two non-diabetic population-based samples comprising N = 697 and N = 1344 adults.
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients.