|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Graft Rejection
|
0.200 |
Biomarker
|
phenotype |
RGD |
Suppressive effects of interleukin-18 on liver function in rat liver allografts.
|
21962809 |
2012 |
|
Mammary Neoplasms, Experimental
|
0.200 |
Biomarker
|
phenotype |
RGD |
Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation.
|
18959458 |
2008 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Rheumatoid Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
IL-18BP is a natural antagonist of pro-inflammatory IL-18 cytokine linked to autoimmune disorders like rheumatoid arthritis.
|
27649785 |
2016 |
|
Rheumatoid Arthritis
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Basal mRNA (4.5-fold) and protein levels of IL-18 were increased and IL-18BP mRNA expression was decreased (8-fold) in RA patients when compared to controls.
|
17367819 |
2007 |
|
Rheumatoid Arthritis
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Unstimulated whole blood samples from RA patients showed lower levels of IL-18BP mRNA expression than those from healthy controls.
|
15188356 |
2004 |
|
Rheumatoid Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
IL-18BP may be a tool for RA therapy because of its ability to neutralize endogenous IL-18.
|
12632414 |
2003 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Through virtual screening of the National Cancer Institute Diversity Set II and in vitro competitive ELISA we have identified three compounds (NSC201631, NSC80734, and NSC61610) that disrupt hIL-18 binding to the ectromelia virus IL-18BP.
|
28352119 |
2017 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
This review will summarize the biology of the IL-18/IL-18R/IL-18BP system and will address the role of IL-18 and its inhibitor, IL-18BP, in cancer biology and immunotherapy.
|
25548255 |
2015 |
|
Immune thrombocytopenic purpura
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In addition to this, we recruited 80 healthy volunteers in order to investigate the possible association between the imbalance of IL-18 and IL-18 BP expressions and the pathogenesis of ITP.
|
23556537 |
2014 |
|
Immune thrombocytopenic purpura
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The elevated levels of IL18/IL18BP in plasma during active stages of disease suggest a possible role in the pathogenesis and course of ITP.
|
19077159 |
2009 |
|
Immune thrombocytopenic purpura
|
0.030 |
Biomarker
|
disease |
BEFREE |
High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura.
|
19797730 |
2009 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Since regulation of IL-18 activity likely contributes to the pathogenesis of inflammatory diseases as well as malignancies, we investigated gene expression of IL-18 binding protein (IL-18BP) in different human cell systems, namely in the keratinocyte cell line HaCaT, in the colon carcinoma cell line DLD-1, and in primary renal mesangial cells.
|
10673399 |
2000 |
|
Hepatitis
|
0.020 |
Biomarker
|
group |
BEFREE |
Inherited human IL-18BP deficiency thus underlies fulminant HAV hepatitis by unleashing IL-18.
|
31213488 |
2019 |
|
Hepatitis A
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inherited human IL-18BP deficiency thus underlies fulminant HAV hepatitis by unleashing IL-18.
|
31213488 |
2019 |
|
Pulmonary Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We have previously demonstrated the protective effects of IL-18 binding protein (IL-18BP) against bleomycin (BLM)-induced pulmonary fibrosis (PF) via inhibition of epithelial-to-mesenchymal transition.
|
30870716 |
2019 |
|
Pulmonary Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Neutralization of IL-18 by IL-18BP improved the survival rate and ameliorated BLM-induced PF in mice, which was associated with attenuated pathological changes, reduced collagen deposition, and decreased content of transforming growth factor-β1 (TGF-β1).
|
30527805 |
2019 |
|
Renal fibrosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
IL-18 binding protein (IL-18BP) is able to neutralize IL-18 biological activity and has a protective effect against renal fibrosis.
|
30527805 |
2019 |
|
Macrophage Activation Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A large number of studies in patients and animal models pointed to the imbalance in IL-18/IL-18BP levels, causing increased systemic levels of free bioactive IL-18, as a predisposing factor in the development of MAS.
|
31192813 |
2019 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Finally, the combination of a natural IL-18 inhibitor (IL-18BP) and a PD-1/PD-L1 inhibitor suppressed tumor growth and metastasis in a murine pancreatic cancer model.
|
29599908 |
2018 |
|
Adult-Onset Still Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
This is the first clinical study to determine if interleukin (IL)-18 inhibition, using the recombinant human IL-18 binding protein, tadekinig alfa, is a therapeutic option in AOSD.
|
29472362 |
2018 |
|
Renal fibrosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
IL-18BP is able to neutralize IL-18 biological activity and has a protective effect against renal fibrosis.
|
30301527 |
2018 |
|
Macrophage Activation Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data indicate that endogenous IL-18BP exerts a protective role in CpG-induced MAS and that IL-18, which acts upstream of IFN-γ, is involved in the severity of MAS.
|
29295842 |
2018 |
|
Ectromelia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Through virtual screening of the National Cancer Institute Diversity Set II and in vitro competitive ELISA we have identified three compounds (NSC201631, NSC80734, and NSC61610) that disrupt hIL-18 binding to the ectromelia virus IL-18BP.
|
28352119 |
2017 |