|
Papillary thyroid carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that SNP rs944289 predisposes to PTC through a previously uncharacterized, long intergenic noncoding RNA gene (PTCSC3) that has the characteristics of a tumor suppressor.
|
22586128 |
2012 |
|
Papillary thyroid carcinoma
|
0.340 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Our data suggest that SNP rs944289 predisposes to PTC through a previously uncharacterized, long intergenic noncoding RNA gene (PTCSC3) that has the characteristics of a tumor suppressor.
|
22586128 |
2012 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Our data suggest that SNP rs944289 predisposes to PTC through a previously uncharacterized, long intergenic noncoding RNA gene (PTCSC3) that has the characteristics of a tumor suppressor.
|
22586128 |
2012 |
|
Thyroid carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.
|
25562676 |
2015 |
|
Malignant neoplasm of thyroid
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.
|
25562676 |
2015 |
|
Thyroid Neoplasm
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.
|
25562676 |
2015 |
|
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.
|
25562676 |
2015 |
|
Papillary thyroid carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Expression data from PTC cell lines pinpointed S100A4 as the most significantly downregulated gene in the presence of PTCSC3.
|
26274343 |
2015 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
S100A4 was upregulated in tumor tissue (P = 9.33 × 10(-7)) while PTCSC3 was strongly downregulated (P = 2.2 × 10(-16)).
|
26274343 |
2015 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
We aimed to find evidence for a link between the expression of PTCSC3 and thyroid carcinogenesis.
|
26274343 |
2015 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data provide strong support for future studies on the role of PTCSC3 in the pathogenesis of LAA stroke and the association between LAA stroke development and thyroid function.
|
27025970 |
2016 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of PTCSC3 as a Novel Locus for Large-Vessel Ischemic Stroke: A Genome-Wide Association Study.
|
27025970 |
2016 |
|
Papillary thyroid carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
MBIP and PTCSC3 displayed lower expression in PTC tissue in males than in females (p = 0.025 and p = 0.036, respectively).
|
27342578 |
2016 |
|
Papillary thyroid carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is a novel lncRNA that was primarily detected in papillary thyroid carcinoma.
|
28187755 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Additionally, the overexpression of lncRNA PTCSC3 inhibited the migration and invasion of U87 and U251 cells.
|
28187755 |
2017 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression level of lncRNA PTCSC3 in human microglia and glioma cell lines was examined using quantitative real-time polymerase chain reaction (qRT-PCR).
|
28187755 |
2017 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
In vivo experiments verified the fact that overexpressed PTCSC3 inhibited tumor growth.
|
28513866 |
2017 |
|
Thyroid carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that PTCSC3 (Thyroid Carcinoma Susceptibility Candidate 3), miR-574-5p and Wnt/β-catenin were involved in PTC, but the potential pathogenic mechanism among them was still unclear.
|
28513866 |
2017 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
LncRNA PTCSC3 is a tumor suppressor in thyroid cancer, and its role in drug resistance of anaplastic thyroid cancer (ATC) to chemotherapy drug doxorubicin was investigated in this study.
|
29561707 |
2018 |
|
Thyroid carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
LncRNA PTCSC3 is a tumor suppressor in thyroid cancer, and its role in drug resistance of anaplastic thyroid cancer (ATC) to chemotherapy drug doxorubicin was investigated in this study.
|
29561707 |
2018 |
|
Malignant neoplasm of thyroid
|
0.040 |
Biomarker
|
disease |
BEFREE |
LncRNA PTCSC3 is a tumor suppressor in thyroid cancer, and its role in drug resistance of anaplastic thyroid cancer (ATC) to chemotherapy drug doxorubicin was investigated in this study.
|
29561707 |
2018 |
|
Thyroid Neoplasm
|
0.040 |
Biomarker
|
disease |
BEFREE |
LncRNA PTCSC3 is a tumor suppressor in thyroid cancer, and its role in drug resistance of anaplastic thyroid cancer (ATC) to chemotherapy drug doxorubicin was investigated in this study.
|
29561707 |
2018 |
|
Anaplastic thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Over-expressed PTCSC3 inhibited the drug resistance of ATC to doxorubicin.
|
29561707 |
2018 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Long noncoding RNA (lncRNA) PTCSC3 (hereafter PTCSC3 is used to represent lncRNA PTCSC3) inhibits glioma and thyroid cancer, indicating its potential tumor suppression function in other types of cancers.
|
31026090 |
2019 |
|
Thyroid carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Long noncoding RNA (lncRNA) PTCSC3 (hereafter PTCSC3 is used to represent lncRNA PTCSC3) inhibits glioma and thyroid cancer, indicating its potential tumor suppression function in other types of cancers.
|
31026090 |
2019 |