Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.
|
9431842 |
1997 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The present meta-analysis suggests that the AT(1) receptor 1166 AC/CC genotype is associated with susceptibility to hypertension in the Chinese population.
|
20223791 |
2010 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The A1166C polymorphism of the AT1 receptor gene (AT1R/A1166C) is associated with hypertension in Caucasians, but not in Japanese.
|
15492474 |
2004 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Therefore, we conducted an association study between A1166C variants of the AT1 receptor gene and hypertension in the Japanese population.
|
12627871 |
2003 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We have investigated whether the A1166C polymorphism of the angiotensin II type 1 (AT1) receptor gene modulates the effects of angiotensin II on collagen type I turnover and myocardial stiffness in hypertension.
|
14597852 |
2003 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The first paper on the genetic role of the AT1 gene in human hypertension has just been published.
|
7743157 |
1995 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension.
|
25990648 |
2015 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
1.Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly.2.
|
10405780 |
1999 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
From the present data it is unlikely that any one of the nine newly characterized SNPs in the promoter region of AT1 gene is associated with arterial hypertension.
|
10726712 |
2000 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
To address the hypothesis that increased myocardial AT1 receptor density causes cardiac hypertrophy apart from high blood pressure we developed a transgenic rat model which expresses the human AT1 receptor under the control of the alpha-myosin heavy-chain promoter specifically in the myocardium.
|
11692158 |
2001 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The AT1 receptor promotes various intracellular signaling pathways resulting in hypertension, endothelial dysfunction, vascular remodeling and end organ damage.
|
28527699 |
2017 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Losartan is a selective antagonist of AngⅠ type (AT1) receptor of Angiotensin Ⅱ (Ang Ⅱ), which is widely used as a clinical medicine for the hypertension.
|
28483563 |
2017 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension.
|
30842613 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggested that in vivo expression of h-chymase caused mild hypertension (AT1 receptor-dependent) with left ventricular hypertrophy (partially AT1 receptor-dependent), and also chronic inflammatory changes (AT1 receptor-independent).
|
14620933 |
2003 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Findings support that FPH is associated with a vascular hyper-sympathetic activation, involving a tonic facilitation of prejunctional AT1 receptors by endogenous Ang II, which can justify, at least in part, the development of hypertension.
|
30326265 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, the BP response to AT1 receptor blockers varied significantly among individuals with hypertension.
|
24131669 |
2014 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The finding of polymorphic sites in the functional promoter of the human AT1 locus will be beneficial to the study of the role of the AT1 receptor gene in hypertension and other cardiovascular diseases.
|
10738546 |
1999 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present work, we explored the changes in the expression of angiotensin II receptor, type 1 (AT<sub>1</sub> receptor) in limbic structures, as well as the effect of the AT1 receptor antagonist losartan in a model of comorbid hypertension and epilepsy.
|
29223539 |
2018 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that chronic elevation of Ang IV in the brain can induce hypertension that can be treated with angiotensin II AT1 receptor antagonists.
|
15117826 |
2004 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
AS-ODNs, targeted to AT1 receptors (AT1R), angiotensinogen (AGT), angiotensin converting enzyme (ACE) and beta 1-adrenergic receptors effectively reduce hypertension in rat models (SHR, 2K-1C and cold-induced) hypertension.
|
11727501 |
2001 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Vascular angiotensin AT2 receptors in hypertension and ageing.
|
18307726 |
2008 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, our data show that spinal ionotropic glutamatergic and AT1 receptors contribute to increased rSNA in the 2K1C model, leading to the maintenance of hypertension; however, the participation of spinal AT1 receptors seems to be especially important in the establishment of sympathoexcitation in this model.
|
29935157 |
2018 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Compound 21 (C21), selective AT2 receptor agonist, has cardioprotective effects in experimental models of hypertension and myocardial infarction.
|
30187136 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that the AGT and AT1 receptor genes are not major genetic determinants of hypertension associated with NIDDM in this population, although we can not exclude the possibility that these loci make a minor contribution in a polygenic context.
|
9218178 |
1997 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.
|
26787451 |
2016 |