|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
1.Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly.2.
|
10405780 |
1999 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although exogenous angiotensin II (AngII) can increase NMDAR activity in the PVN, whether endogenous AT1 receptor-protein kinase C (PKC) activity mediates the augmented NMDAR activity of PVN presympathetic neurons in hypertension is unclear.
|
31241170 |
2019 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Aortic collagen, aortic stiffness, and AT1 receptors in experimental and human hypertension.
|
8946073 |
1996 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
AS-ODNs, targeted to AT1 receptors (AT1R), angiotensinogen (AGT), angiotensin converting enzyme (ACE) and beta 1-adrenergic receptors effectively reduce hypertension in rat models (SHR, 2K-1C and cold-induced) hypertension.
|
11727501 |
2001 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Candesartan, an AT(1) receptor antagonist, has been reported to have no association with persistent cough in subjects with hypertension, but there has been no study on the safety of its administration to hypertensive patients with symptomatic asthma.
|
11457745 |
2001 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension.
|
30842613 |
2019 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Compound 21 (C21), selective AT2 receptor agonist, has cardioprotective effects in experimental models of hypertension and myocardial infarction.
|
30187136 |
2019 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Findings support that FPH is associated with a vascular hyper-sympathetic activation, involving a tonic facilitation of prejunctional AT1 receptors by endogenous Ang II, which can justify, at least in part, the development of hypertension.
|
30326265 |
2019 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
From the present data it is unlikely that any one of the nine newly characterized SNPs in the promoter region of AT1 gene is associated with arterial hypertension.
|
10726712 |
2000 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, the BP response to AT1 receptor blockers varied significantly among individuals with hypertension.
|
24131669 |
2014 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
G4+/- offspring on a HFD displayed early hypertension associated with increased renal gene expression of renin and the AT1- receptors compared to G4+/- on a C diet.
|
28750406 |
2017 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present work, we explored the changes in the expression of angiotensin II receptor, type 1 (AT<sub>1</sub> receptor) in limbic structures, as well as the effect of the AT1 receptor antagonist losartan in a model of comorbid hypertension and epilepsy.
|
29223539 |
2018 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we discuss the role of renin-angiotensin system (RAS) in hypertension; the current gene delivery/gene transfer systems and the RAS as a target for gene therapy to treat hypertension; the successful use of retroviral vectors to deliver antisense to the AT1 receptor (AT1-AS) to prevent the development of hypertension and cardiovascular pathophysiology; the potential use of the viral vectors for the reversal of hypertension; and the future of antisense gene therapy and potential advantages and limitations of this regimen in the treatment and/or control of hypertension.
|
10779083 |
2000 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Losartan is a selective antagonist of AngⅠ type (AT1) receptor of Angiotensin Ⅱ (Ang Ⅱ), which is widely used as a clinical medicine for the hypertension.
|
28483563 |
2017 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data indicate an essential and systemic role for TG2 in bridging inflammation to hypertension via its posttranslational modifications stabilizing AT1 receptor and sensitizing Ang II.
|
30715101 |
2019 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension.
|
25990648 |
2015 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.
|
26787451 |
2016 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Regulatory actions of angiotensin II (AngII), which is involved in the pathophysiology of hypertension and also participates in cell proliferation and cell differentiation, are mainly mediated by AngII type 1 (AT1) receptor.
|
9330590 |
1997 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Systemic delivery of recombinant adeno-associated virus with DNA antisense to AT(1) receptors in adult rodents decreases hypertension for up to 6 months.
|
11566928 |
2001 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The AT1 receptor promotes various intracellular signaling pathways resulting in hypertension, endothelial dysfunction, vascular remodeling and end organ damage.
|
28527699 |
2017 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The A1166C polymorphism of the AT1 receptor gene (AT1R/A1166C) is associated with hypertension in Caucasians, but not in Japanese.
|
15492474 |
2004 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established.
|
24414230 |
2014 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The finding of polymorphic sites in the functional promoter of the human AT1 locus will be beneficial to the study of the role of the AT1 receptor gene in hypertension and other cardiovascular diseases.
|
10738546 |
1999 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The first paper on the genetic role of the AT1 gene in human hypertension has just been published.
|
7743157 |
1995 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The present meta-analysis suggests that the AT(1) receptor 1166 AC/CC genotype is associated with susceptibility to hypertension in the Chinese population.
|
20223791 |
2010 |