|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Obesity and diabetes were associated with increased leptin and decreased adiponectin plasma levels, higher protein expression of leptin and IL-6 in SAT, and higher visfatin protein expression in EAT.
|
31533725 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
NAMPT-mediated NAD<sup>+</sup> biosynthesis is indispensable for adipose tissue plasticity and development of obesity.
|
29551635 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis.
|
28333140 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate if genetic variations in the visfatin gene (SNPs rs7789066/ rs11977021/rs4730153) could modify the cardiovascular-risk (CV-risk) despite the metabolic phenotype (obesity and glucose tolerance).
|
27166797 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The association of Pre-B cell colony enhancing factor 1 (PBEF1) with obesity, together with its pro-inflammatory properties suggests that PBEF1 might be another crucial mediator that links inflammation with obesity and primary osteoarthritis (OA).
|
26752339 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this Review, we discuss current understanding of the functions of NAMPT and highlight progress made in identifying the physiological role of NAMPT and its relevance in various human diseases and conditions, such as obesity, NAFLD, T2DM, cancer and ageing.
|
26215259 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the NAMPT gene, which encodes the adipocytokine visfatin/nicotinamide phosphorybosil transferase (NAMPT), affect the circulating visfatin/NAMPT levels and are associated with obesity and cardiovascular diseases.
|
24100423 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hepatic overexpression of miR-34a reduced NAMPT/NAD(+) levels, increased acetylation of the SIRT1 target transcriptional regulators, PGC-1α, SREBP-1c, FXR, and NF-κB, and resulted in obesity-mimetic outcomes.
|
23834033 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results demonstrate the association of the common variants of IL6, LEPR, and PBEF1 with obesity in Indian children.
|
22228719 |
2012 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes.
|
21687707 |
2011 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
NAMPT circulating concentrations (P<0.01) and gene expression levels in PBC (P<0.05) were significantly increased in obese patients as compared to lean subjects.
|
20106640 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leucocytes are a major source of enzymatically active NAMPT, which may serve as a biomarker or even mediator linking obesity, inflammation and insulin resistance.
|
21298414 |
2011 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A cross-sectional analysis of human subjects showed that athletes had about a twofold higher skeletal muscle NAMPT protein expression compared with sedentary obese, nonobese, and type 2 diabetic subjects (P < 0.05).
|
19887595 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, visfatin/PBEF/Nampt expression was significantly upregulated in obese type 2 diabetic patients, whereas obese nondiabetics exhibited similar levels compared to lean controls, indicating that visfatin/PBEF/Nampt levels are related to type 2 diabetes rather than to obesity.
|
20091460 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was aimed at investigation of the possibility that single-nucleotide polymorphisms (SNPs) in the visfatin gene are associated with either obesity or type 2 diabetes (T2D).
|
19300429 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show: (1) A strong association between rs9939609 SNP of the FTO gene variant and obesity in Spanish morbidly obese adult patients; (2) positive correlations between FTO mRNA and leptin, perilipin, and visfatin gene expressions in subcutaneous adipose tissue; (3) FTO and perilipin gene expressions were positively correlated in visceral fat depot.
|
18855084 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, PBEF1 G-948T is associated with increased high-density lipoprotein cholesterol; but genetic variation in PBEF1 does not seem to have a major impact on the development of obesity or on the expression of the gene.
|
18940394 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated the effects of genetic variations in the visfatin gene (pre-B-cell colony-enhancing factor 1 [PBEF1]) on obesity, metabolic parameters, and blood pressure (BP) in 2 children cohorts.
|
17512309 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated the role of genetic variation in the visfatin gene in the pathophysiology of obesity/type 2 diabetes mellitus (T2DM).
|
16636125 |
2006 |