CELA3A, chymotrypsin like elastase 3A, 10136

N. diseases: 16; N. variants: 1
Disease: Fatty Liver Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4529962
Disease: Fatty Liver Disease
Fatty Liver Disease 		0.010 Biomarker disease BEFREE The present study used OCA and ELA to compare the effects of mono- and combination therapies on metabolic and histological endpoints in Lep<sup>ob/ob</sup> mice with established diet-induced and biopsy-confirmed NASH (ob/ob-NASH). ob/ob-NASH mice were fed the AMLN diet high in trans-fat, fructose and cholesterol for 15 weeks, whereafter they received vehicle, OCA (30 mg/kg, PO, QD), ELA (3, 10 mg/kg, PO, QD), or combinations (OCA + ELA) for eight weeks. 31227742 2019