CDK2, cyclin dependent kinase 2, 1017

N. diseases: 270; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.400 GeneticVariation disease BEFREE Joint segregation results show linkage of a CDKN2-like DNA polymorphism with UV-B-induced melanoma formation in these hybrids. 8917541 1996
CUI: C0025202
Disease: melanoma
melanoma 		0.400 GeneticVariation disease BEFREE In seven kindreds (including our six largest), CDKN2 mutations were found to segregate with the putative melanoma chromosome previously assigned by 9p haplotype analysis. 8595405 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Loss of heterozygosity studies in melanoma and pancreatic carcinoma from gene carriers strongly support the view that CDKN2 is a general tumour suppressor gene predisposing not only to melanoma but also to other malignancies. 7640518 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE CDKN2 has been implicated as a melanoma susceptibility gene in some kindreds with a family history of this disease. 8570179 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE The gene encoding the cell cycle inhibitor p16INK4A (also known as p16, MTS1, CDKN2 and INK4) has been mapped to human chromosome band 9p21, a region that also contains a putative melanoma susceptibility gene. 7624155 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE To test the role of CDKN2 in human melanoma metastasis, 14 human melanoma cell lines with different metastatic abilities in nude mice were analysed for possible abnormalities in the CDKN2 gene. 7478563 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Inhibition of the melanoma cell cycle and regulation at the G1/S transition by 12-O-tetradecanoylphorbol-13-acetate (TPA) by modulation of CDK2 activity. 7589260 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.400 GeneticVariation disease BEFREE The spectrum of the CDKN2 mutations found in melanoma cell lines indicated a major role for ultraviolet light in generating the mutations, suggesting the mutations occurred in vivo. 7700630 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.400 GeneticVariation disease BEFREE Mutations of CDKN2 have been found recently in melanoma and many other tumor types. 7743501 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Recently, the inhibitor of cyclin-dependent kinase 4 (CDK4I; also known as p16INK4, multiple tumor suppressor 1, or CDKN2 gene) has been mapped to 9p21 and shown to be mutated or deleted in a large fraction of cell lines derived from many tumor types, including melanoma, suggesting that this gene could be a melanoma suppressor gene. 7923152 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 Biomarker disease BEFREE PEITC may induce G0/G1 cell-cycle arrest through affecting the proteins such as cdk2, cyclin E, and p21 in GBM 8401 cells. 26678675 2017
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 Biomarker disease BEFREE Thus, two distinct RNA-based mechanisms activate this novel KAP/ROCK2/Cdk2-dependent invasion pathway in glioblastoma. 24704824 2015
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 AlteredExpression disease BEFREE It targets CDK2, 7 and 9 preferentially, which are also overexpressed in glioblastoma. 26151768 2015
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 Biomarker disease BEFREE Further analysis showed that NRAS and CDK2 were positively related with GBM. 24967941 2014
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 GeneticVariation disease BEFREE CDKN2 deletions occurred in GBM from patients somewhat older than those patients with GBM lacking CDKN2 deletion (mean age 53 vs. 48 years). 9217972 1997
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 GeneticVariation disease BEFREE Using a comparative multiplex PCR assay, homozygous deletions of the CDKN2/p16 gene were detected in 5 anaplastic astrocytomas (25%) and 6 GBMs (46%), but in none of the lower-grade tumors. 8857999 1996
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 GeneticVariation disease BEFREE Thirty-six of 42 GBMs (86%) had alterations of either CDKN2/p16 (n = 22), RB (n = 10), or both (n = 4); these two genetic changes, however, were relatively exclusive (P = 0.003). 8548755 1996
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 Biomarker disease BEFREE These data support a role for MTS1/p16/CDKN2 as a tumor suppressor gene in the in vivo evolution of GBMs. 7887443 1995
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.380 GeneticVariation disease UNIPROT
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.340 Biomarker disease CTD_human Upregulation of cell cycle genes in head and neck cancer patients may be antagonized by erufosine's down regulation of cell cycle processes in OSCC cells. 29464035 2018
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.340 Biomarker disease BEFREE CDK2(-/-) MEF and CDK2 HNSCC knockdown cell cultures were more radiosensitive than the corresponding controls. 23461792 2013
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.340 Biomarker disease BEFREE Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma. 9378820 1997
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.340 Biomarker disease BEFREE CDKN2 does not appear to be the only TSG on 9p21 in HNSCC, and our results suggest that another region of deletion exists proximal to the IFNW locus. 7542912 1995
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.340 GeneticVariation disease BEFREE Sixty-eight primary head and neck squamous cell carcinomas and nine head and neck squamous cell carcinoma cell lines were examined for mutations and homozygous deletions of the p16/CDKN2 gene. 7923115 1994
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma 		0.330 Biomarker disease BEFREE Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas. 18156799 2007