|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As an oncogenic kinase, recent studies have shown that ACK1 plays a critical regulatory role in the initiation and progression of tumors.
|
31772931 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conversely, pharmacological inhibition by ACK1 inhibitor, (R)-9bMS mitigated CD44<sup>+</sup>PSA<sup>-/lo</sup> sphere formation, overcame resistance to radiation-induced cell death, induced significant apoptosis in PCSCs and inhibited CD44<sup>+</sup>PSA<sup>-/lo</sup> xenograft tumor growth in castrated mice suggesting dependency of PCSCs on ACK1 for survival.
|
29386546 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We demonstrate that knockdown of TNK2 expression can substantially suppress the invasiveness and proliferation advantage of TNBC cells in vitro and tumor formation in xenograft mouse models.
|
27902967 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We aimed to investigate ACK1 protein expression in colorectal mucosa with inflammation and neoplasm, and to evaluate its correlation with disease activity and severity.
|
27926694 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Ack1 tyrosine kinase is overexpressed in prostate cancer and promotes castrate resistant xenograft tumor growth and enhances androgen target gene expression and AR recruitment to enhancers.
|
25950519 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, ACK1 expression in "normal" tissue adjacent to tumour, but not tumour, was independently associated with poor overall and relapse-free survival.
|
24461128 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Oncogenicity of ACK1 is not only due to its ability to promote activation of critical pro-survival kinases and harmone receptors by phosphorylating at distinct tyrosine residues, but also by employing a similar mechanism to eliminate a tumor suppressor from cancer cells.
|
23597703 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It also provides a rationale to target ACK1 in combination with other chemotherapeutic drugs, such as EGFR inhibitors, to potentiate therapeutic action against resistant tumors.
|
20359967 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Two intracellular tyrosine kinases, Ack1 (activated cdc42-associated kinase) and Src, phosphorylate and enhance AR activity and promote prostate xenograft tumor growth in castrated animals.
|
20383201 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Amplification of the TNK2 gene in primary tumours correlates with poor prognosis.
|
18435854 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of AR point mutants inhibited Ack1-driven xenograft tumor growth.
|
17494760 |
2007 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We identified amplification of the ACK1 gene in primary tumors, which correlates with poor prognosis.
|
16247015 |
2005 |