TNK2, tyrosine kinase non receptor 2, 10188

N. diseases: 59; N. variants: 6
Disease: Tumor Progression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Previous studies have demonstrated that ACK1 was involved with multiple signaling pathways of tumor progression. 31772931 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 GeneticVariation phenotype BEFREE The work demonstrates that other than gene amplification, a single somatic mutation in ACK1 can result in extended protein stability enabling the oncoprotein to exert its oncogenic function in tumor progression. 20359967 2010