The aim of this study was to investigate if variations in the proximal promoter and the coding region of the CDKN1C and CDK4 genes are associated with type 2 diabetes or changes in related quantitative phenotypes among glucose-tolerant subjects.
We aimed at identifying a role of CDK4 IVS4-nt40G --> A variant in T2D-associated obesity (body mass index, BMI > or = 30) by association tests in an Italian T2D subjects dataset.
Protein levels of p16<sup>Ink4a</sup> and p15<sup>Ink4b</sup> were also diminished in T2DM-CAD patients while CDK4 levels, the main target of p16<sup>Ink4a</sup> and p15<sup>Ink4b</sup>, were augmented in T2DM and T2DM-CAD subjects.