CDK4, cyclin dependent kinase 4, 1019

N. diseases: 433; N. variants: 8
Disease: Diabetes Mellitus, Non-Insulin-Dependent ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 AlteredExpression disease BEFREE Protein levels of p16<sup>Ink4a</sup> and p15<sup>Ink4b</sup> were also diminished in T2DM-CAD patients while CDK4 levels, the main target of p16<sup>Ink4a</sup> and p15<sup>Ink4b</sup>, were augmented in T2DM and T2DM-CAD subjects. 30176239 2019
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation disease BEFREE We aimed at identifying a role of CDK4 IVS4-nt40G --> A variant in T2D-associated obesity (body mass index, BMI > or = 30) by association tests in an Italian T2D subjects dataset. 19634152 2009
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation disease BEFREE CDK4 IVS4-nt40G-->A SNP and type 2 diabetes in Italians. 19695727 2009
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation disease BEFREE The aim of this study was to investigate if variations in the proximal promoter and the coding region of the CDKN1C and CDK4 genes are associated with type 2 diabetes or changes in related quantitative phenotypes among glucose-tolerant subjects. 15821902 2005