CDK4, cyclin dependent kinase 4, 1019

N. diseases: 433; N. variants: 8
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.030 GeneticVariation disease BEFREE We aimed at identifying a role of CDK4 IVS4-nt40G --> A variant in T2D-associated obesity (body mass index, BMI > or = 30) by association tests in an Italian T2D subjects dataset. 19634152 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.030 GeneticVariation disease BEFREE CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - a case-control study. 19327170 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.030 GeneticVariation disease BEFREE The db/db-CDK4(R24C) mice present a novel model of leptin-resistant obesity with compensatory hyperinsulinemia and normalized blood glucose levels, and thus may be useful for future studies that aim to dissect relationships between insulin and leptin signaling. 18678431 2008