|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We retrospectively reviewed 13 DLOS patients (six men, seven women; median age 32 years (interquartile range (IQR) 27 to 38)) diagnosed using the following criteria: the histological coexistence of low-grade and high-grade osteosarcoma components in the lesion, and positive immunohistochemistry of mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase 4 (CDK4) associated with MDM2 amplification.
|
31154837 |
2019 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data highlight that CDK4 may be a potential promising therapeutic target in the treatment of human osteosarcoma.
|
29452249 |
2018 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The FD and osteosarcoma were negative for CDK4.
|
29268950 |
2018 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that miR-506-3p acts as a tumor suppressor in osteosarcoma and that its downregulation leads to tumor cell proliferation and metastasis due to upregulation of RAB3D- and CDK4-mediated signaling. miR-506-3p thus appears be a potentially useful target for adjuvant therapy in osteosarcoma patients.
|
29905536 |
2018 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Several differentially methylated sites were associated with upregulation of SEZ6L2, KIRREL, CEP72 and CDK4 and may have an important role in the pathogenesis of osteosarcomas through promotion of cell proliferation and metastasis.
|
28560411 |
2017 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, when compared with low-grade central and parosteal osteosarcomas, MDM2 and CDK4 markers cannot be used diagnostically to differentiate this subtype of osteosarcoma.
|
25680902 |
2015 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.
|
24835790 |
2014 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
G-banding, comparative genomic hybridization (CGH), and real-time PCR for the MDM2 and CDK4 genes were performed to describe the genetic profile of this tumor and revealed aberrations that are common findings of parosteal osteosarcomas.
|
22749040 |
2012 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To test this, we performed MDM2 and CDK4 immunohistochemistry on 81 primary and 26 recurrent/metastatic high-grade osteosarcomas and correlated these data with the histology of the primary resection material, with particular attention to the potential presence of any coexisting low-grade osteosarcomatous components.
|
22301501 |
2012 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed that MDM2 and/or CDK4 immunoreactivity was present in 89% of low-grade osteosarcoma specimens.
|
21336260 |
2011 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma.
|
20196171 |
2010 |
|
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this paper, the presence of SV40-like sequences was investigated in 54 Japanese osteosarcomas in which mutations of the retinoblastoma (Rb), p53, MDM2, and CDK4 genes had been already analysed.
|
10817503 |
2000 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Strong and uniform CDK4 and MDM2 immunoreactivity was found respectively in three of three and two of three dedifferentiated parosteal osteosarcomas.
|
10943202 |
2000 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study evaluated SAS gene amplification, and MDM2 and CDK4 protein expression in 20 tumor samples of central low-grade osteosarcoma (16 primary, 3 recurrences, 1 lung metastasis).
|
10101594 |
1999 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To investigate the role of mechanisms regulating cell-cycle progression in human osteosarcomas (OS), pRb/p16/cdk4 expression was analyzed in 39 high-grade OS; 19 of these developed metastasis during follow-up.
|
10502725 |
1999 |
|
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To examine INK4A gene alterations in uncultured samples of osteosarcoma and the relationship between INK4A and CDK4 alterations, we analyzed the INK4A and CDK4 genes in 87 specimens from 79 patients.
|
9935200 |
1999 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore sought to determine whether the CDKN2A and CDK4 genes were altered in those osteosarcomas that lacked RB inactivation.
|
9665476 |
1998 |
|
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also investigated the relationship of CDK4 amplification with retinoblastoma (RB) gene mutations in osteosarcomas, for which we have already performed the mutation analyses in detail.
|
9703873 |
1998 |