CDK4, cyclin dependent kinase 4, 1019

N. diseases: 433; N. variants: 8
Disease: Rhabdomyosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.050 AlteredExpression disease BEFREE CDK4/6 inhibitors have antiproliferative activity in CDK4-amplified liposarcoma and neuroblastoma, suggesting CDK4/6 inhibition as a potential therapeutic strategy in fusion-positive RMS. 25810375 2015
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.050 Biomarker disease BEFREE CDK4 is preclinically validated as a therapeutic target in PAX3-FOXO1 fusion gene-positive rhabdomyosarcomas. 26199390 2015
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.050 AlteredExpression disease BEFREE Genes identified such as CDK4 and MYCN are known to be amplified, overexpressed, and involved in RMS tumorigenesis. 19235922 2009
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.050 GeneticVariation disease BEFREE Among LMS and RMS most cases with CDK4, MDM2 and GLI gene alterations also showed a simultaneous high expression of the relative protein. 15024701 2004
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.050 Biomarker disease BEFREE An osteosarcoma cell line, OsACL, manifested a 25-fold increased copy number of CDK4, amplified concordantly with both GLI and MDM2, whereas a rhabdomyosarcoma cell line, SJRH30, was found to have an amplicon that included CDK4 and GLI but not MDM2. 8221695 1993