CDK4, cyclin dependent kinase 4, 1019

N. diseases: 433; N. variants: 8
Disease: Stomatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038362
Disease: Stomatitis
Stomatitis 		0.020 GeneticVariation disease BEFREE The highest class-specific risks were neutropenia grade 3-4 for CDK4/6 inhibitors (OR 40.77; 95% CI 19.52-85.19), stomatitis grade 3-4 for mTOR inhibitors (OR 11.92; 95% CI 3.68-38.57), hyperglycemia grade 3-4 for PI3K inhibitors (OR 40.93; 95% CI 10.08-166.22) and diarrhea for anti-HER2 agents (OR 9.93; 95% CI 4.71-20.95). 29108713 2018
CUI: C0038362
Disease: Stomatitis
Stomatitis 		0.020 GeneticVariation disease BEFREE CDK4/6 inhibitors were associated with an increased risk of fatigue, alopecia and stomatitis. 28699811 2017