CDK4, cyclin dependent kinase 4, 1019

N. diseases: 433; N. variants: 8
Disease: Fibrous Dysplasia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0259779
Disease: Fibrous Dysplasia
Fibrous Dysplasia 		0.020 Biomarker disease BEFREE The FD and osteosarcoma were negative for CDK4. 29268950 2018
CUI: C0259779
Disease: Fibrous Dysplasia
Fibrous Dysplasia 		0.020 AlteredExpression disease BEFREE Our findings confirm that FD can rarely exhibit locally aggressive behaviour with extension beyond the bone compartment into the surrounding soft tissue; these lesions can be distinguished from low-grade intramedullary osteosarcoma by lack of amplification/overexpression of CDK4 and MDM2 and the presence of a GNAS mutation. 23760783 2013