|
Atypical Lipoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined whether MDM2 and/or CDK4 cause WDLPS/DDLPS, using two types of transformed human bone marrow stem cells (BMSCs), 2H and 5H, with five oncogenic hits (overexpression of hTERT, TP53 degradation, RB inactivation, c-MYC stabilization, and overexpression of HRAS<sup>v12</sup>).
|
31160689 |
2019 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These tumors behave in a benign manner and MDM2/CDK4 negativity may be useful in excluding ALT.
|
29629919 |
2018 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MDM2 and CDK4 were never coexpressed and FISH for MDM2 amplification was consistently negative, highlighting critical biological differences from atypical lipomatous tumor/dedifferentiated liposarcoma.
|
27879515 |
2017 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination therapy with CDK4 and RTK inhibitors may be an effective therapeutic option for WDLPS/DDLPS patients with RTK gene amplification.
|
28099935 |
2017 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry.
|
27597521 |
2017 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate foci resembling well-differentiated liposarcoma in MPT for MDM2 and CDK4 amplification.
|
26542423 |
2016 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite indistinguishable morphology all cases of malignant PT with WDLS-like liposarcomatous differentiation were negative for MDM2 and CDK4 IHC and FISH, supporting different underlying pathogenesis.
|
26843318 |
2016 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipoblastoma (LB) is a rare benign adipocytic tumor of childhood occasionally showing histological similarities to myxoid liposarcoma (ML) or well-differentiated liposarcoma (WDL). p16 immunohistochemistry has proved to be useful in distinguishing various types of liposarcomas, in particular WDL from lipoma, with higher sensitivity and specificity than MDM2 and CDK4 immunohistochemistry.
|
26514741 |
2016 |
|
Atypical Lipoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Histologically, both CDK4 (P=0.007) and JUN (P=0.005) amplifications were associated with dedifferentiated liposarcoma, whereas amplification of the proximal parts of HMGA2 (5'-untranslated region (UTR) and exons 1-3) was associated with atypical lipomatous tumor/well-differentiated liposarcoma (P=0.01).
|
26336885 |
2015 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four cases of atypical lipomatous tumor/well-differentiated liposarcoma (4/26, 15%) with a low MDM2 and CDK4 amplification level (MDM2-CDK4/CEP12 ratio ranging between 2 and 2.5) detected by FISH showed no amplification by MLPA, although gain of MDM2 and CDK4 (ratios ranging between 1.6 and 1.9) was seen with MLPA.
|
25679065 |
2015 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CDK4 amplification predicts recurrence of well-differentiated liposarcoma of the abdomen.
|
25121597 |
2014 |
|
Atypical Lipoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition to classical morphology of atypical lipomatous tumor with evidence of lipoblasts and atypical adipocytes, immunohistochemistry with nuclear murine double-minute type 2 protein and cyclin-dependent kinase-4 expression as well as fluorescence in situ hybridization analysis showing an amplification of murine double-minute type 2 protein and cyclin-dependent kinase-4 were helpful to establish the diagnosis.
|
21358383 |
2011 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An amplification of the MDM2 and CDK4 genes respectively in the atypical lipomatous tumor/well-differentiated liposarcoma areas was detected by fluorescence in situ hybridization (FISH) analysis, and translocations of the CHOP and FUS genes were detected by FISH analysis in the myxoid/round cell liposarcoma areas.
|
18551309 |
2008 |
|
Atypical Lipoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Studies of cell cycle controlling proteins that interact with CDK4 and MDM2 revealed an abnormally strong expression of cyclins D1 and E. The selective high-level amplification of the 5'-part of HMGA2, including the DNA-binding domains, suggests that this gene is a major target of amplifications in WDLS.
|
18160213 |
2008 |
|
Atypical Lipoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) and dedifferentiated liposarcoma (DDL) are reported to have murine double-minute type 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) amplification as a characteristic genetic alteration.
|
16938516 |
2006 |
|
Atypical Lipoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma.
|
10755400 |
2000 |