Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Using mouse xenograft models, we found that the co-overexpression of MDM2 and CDK4 in 5H cells with five additional oncogenic mutations can cause proliferative sarcoma with a DDLPS-like morphology in vivo.
|
31160689 |
2019 |
Malignant neoplasm of soft tissue
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, we report that CDK4 is highly expressed in human synovial sarcoma, and high CDK4 expressions are associated with poor prognosis in sarcomas patients and the clinical stage and the TNM grade in synovial sarcoma patients.
|
29670090 |
2018 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results also indicate that the increase in sarcoma incidence in Polμ<sup>-/-</sup>P53<sup>-/-</sup> mice could be associated with Cdk4 and Kub3 amplification and overexpression.
|
28460268 |
2017 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
We compared sensitivity and specificity of p16 IHC to MDM2 and CDK4 IHC in the differential diagnosis of ALT-WDLPS (n=19) versus benign adipocytic tumors (n=44) and DDLPS (n=18) versus mimicking sarcomas (n=20).
|
27597521 |
2017 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
CDK4/6 Inhibitors Sensitize Rb-positive Sarcoma Cells to Wee1 Kinase Inhibition through Reversible Cell-Cycle Arrest.
|
28619757 |
2017 |
Malignant neoplasm of soft tissue
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Palbociclib is also active in vivo against sarcomas displaying high levels of CDK4 but not against sarcomas displaying low levels of CDK4 and high levels of p16ink4a.
|
26528855 |
2015 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Genes that are frequently amplified in sarcoma include CDK4, YEATS4, HMGA2, MDM2, JUN, DNM3, FLT4, MYCN, MAP3K5, GLI1 and the microRNAs miR-214 and miR-199a2.
|
22387046 |
2012 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Chromosomal enrichment analysis of genes showed a highly significant impact at cytoband 7q22 (chromosome 7) which included mouse double minute (MDM2) and cyclin-dependant kinase (CDK4) as well as other genes associated with human sarcomas.
|
22982072 |
2012 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas.
|
16160477 |
2005 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression and amplification of several genes (MDM2, CDK4 and SAS) located on chromosome 12q13-15 have been noted to occur in various human sarcomas.
|
11564577 |
2001 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Amplification of the cyclin-dependent kinase 4 (CDK4) gene, located at 12q13-q14, has been found as an alternative genetic alteration to CDKN2A inactivation in various human tumors including malignant gliomas and sarcomas.
|
9916925 |
1999 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
However, alterations in other components of the pRh/p16INK4A/ CDK4/cyclin D1/E2F pathway have been proven crucial for tumourigenesis in human sarcomas.
|
9582521 |
1998 |
Malignant neoplasm of soft tissue
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we detected OS4 amplification in 5/5 primary sarcomas with known amplification of the closely linked marker CDK4.
|
9315096 |
1997 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas.
|
8946207 |
1996 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
However, CGH analysis detected amplification of 12q14 also in some tumors where neither MDM2 nor CDK4 was amplified, suggesting that another as yet unknown gene(s) may drive amplification of this region in sarcomas.
|
8527390 |
1995 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Amplifications of CDK4 and CCND1 (cyclin D1) were observed in 11% and 4% of the sarcomas respectively, but never in tumours with CDKN2 deletions.
|
7640224 |
1995 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.
|
8221695 |
1993 |