|
Brain Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Molecular mechanisms of OLIG2 transcription factor in brain cancer.
|
27447975 |
2016 |
|
Brain Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Widespread OLIG2 expression discriminates oligodendroglial neoplasms or DNTs from other clear cell primary brain tumour types.
|
17257132 |
2007 |
|
Brain Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Olig2 and CD99 are useful negative markers for the diagnosis of brain tumors.
|
18552083 |
2008 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Finally, we elucidate the Coherent-Gene Modules (CGMs) networks-framework of OLIG2 involvement in cancer.
|
27447975 |
2016 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Additionally, RelB regulates expression of Olig2, a regulator of cancer stem cell proliferation and a candidate marker for the cell of origin in glioma.
|
23451236 |
2013 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Additionally, RelB regulates expression of Olig2, a regulator of cancer stem cell proliferation and a candidate marker for the cell of origin in glioma.
|
23451236 |
2013 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Finally, we elucidate the Coherent-Gene Modules (CGMs) networks-framework of OLIG2 involvement in cancer.
|
27447975 |
2016 |
|
Mental disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects.
|
22505278 |
2013 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Strikingly, Olig2 cKO mice exhibited an anxious phenotype, aberrant responses to stress, and cognitive deficits.
|
31758330 |
2019 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Re-expression of MAL and OLIG2 to physiological levels dramatically reduced the growth of lung tumor xenografts.
|
24469050 |
2015 |
|
Spinal Cord Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Immunohistochemical and ultrastructural observations revealed that all the tumors were ependymal in nature with positivity for GFAP and epithelial membrane antigen and negativity for oligodendrocyte transcription factor 2, showing intra- and intercellular microrosettes, leading us to a diagnosis of tanycytic ependymoma for the frontal lobe tumor and tanycytic ependymoma with ordinary ependymomatous component for the spinal cord tumors.
|
24612193 |
2014 |
|
Central Nervous System Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
OLIG2 is a useful immunohistochemical marker in differential diagnosis of clear cell primary CNS neoplasms.
|
17257132 |
2007 |
|
Neoplasms, Neuroepithelial
|
0.010 |
Biomarker
|
group |
BEFREE |
Olig-2 stained 22 (91.6%) of 24 oligodendrogliomas and all dysembryoplastic neuroepithelial tumors but also 24 (80%) of 30 glioblastoma multiforme and 8 (80%) of 10 pilocytic astrocytomas.
|
21835431 |
2012 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.
|
16103065 |
2005 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We investigated the expression of OLIG2 by in-situ hybridisation in 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas, and nine non-oligodendroglial tumours (four grade IV astrocytomas, two meningiomas, a dysembryoplastic neuroepithelial tumour, and two metastases).
|
11498220 |
2001 |
|
Thymus Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Gene expression profiling of thymic tumors that developed in OLIG2/LMO1 mice revealed up-regulation of Notch1 as well as Deltex1 (Dtx1) and pre T-cell antigen receptor alpha (Ptcra), two genes that are considered to be downstream of Notch1.
|
16103065 |
2005 |
|
Intellectual Disability
|
0.010 |
Biomarker
|
group |
BEFREE |
Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability.Xu et al.
|
31173710 |
2019 |
|
Abnormal behavior
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects.
|
22505278 |
2013 |
|
Abnormal behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In this study, we conditionally deleted Olig2 in oligodendroglial lineage cells (Olig2 cKO) and screened the behavioral changes in adult mice.
|
31758330 |
2019 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Although we previously showed that OLIG2 expression inhibits glioma cell growth, its role in tumorigenesis remains incompletely understood.
|
17951409 |
2007 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Genome occupancy and expression profiling analyses reveal that Olig2 directly activates cell-proliferation machinery to promote tumorigenesis.
|
27165742 |
2016 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We investigated the expression of OLIG2 by in-situ hybridisation in 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas, and nine non-oligodendroglial tumours (four grade IV astrocytomas, two meningiomas, a dysembryoplastic neuroepithelial tumour, and two metastases).
|
11498220 |
2001 |
|
Recurrent tumor
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
OLIG2 deletion reduces tumor growth and causes an oligodendrocytic to astrocytic phenotype shift, with PDGFRα downregulation and reciprocal EGFR signaling upregulation, underlying alternative pathways in tumor recurrence.
|
28806136 |
2017 |
|
Tumor Initiation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Depletion of mitotic Olig2<sup>+</sup> progenitors or Olig2 ablation impeded tumor initiation.
|
31474569 |
2019 |
|
Psychotic symptom
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We hypothesised that oligodendrocyte lineage transcription factor 2 (OLIG2), a regulator of white matter development and a candidate gene for schizophrenia, may also be associated with psychotic symptoms in AD.
|
19477230 |
2009 |