|
Acute colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
NEW & NOTEWORTHY Here, we identify a new role for growth differentiation factor 11 (GDF11), which ameliorates dextran sodium sulfate-induced acute colitis.
|
30188752 |
2018 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decline in circulating count and survival of VEGFR2<sup>+</sup>/CD133<sup>+</sup> cells with age was accompanied by decrease in their TERT and GDF11 expression levels in patients with AMI.
|
31292540 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, GDF11 has a tumor suppressor role in liver cancer, exerts its effects through Smad2/3 signaling and may serve as a novel tumor marker in liver cancer diagnosis.
|
29545874 |
2018 |
|
Agenesis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We show that GDF11 is cleaved and activated by PCSK5A, but not by PCSK5A-C470R, and that Gdf11-deficient embryos, in addition to having anteroposterior patterning defects and renal and palatal agenesis, also have a presacral mass, anorectal malformation, and exomphalos.
|
18519639 |
2008 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined.
|
30188752 |
2018 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Daily intravenous treatment with GDF11-injection can rejuvenate respects of cognition and cerebrovascular changes in AD mice.
|
29480172 |
2018 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
We suggest that alterations of GDF11 and Tregs are involved in AD progression and that rejuvenation of the immune system is a potential therapeutic strategy in AD.
|
26317549 |
2015 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition to being significantly elevated in ALS CSF, these cytokines negatively correlated with the disease duration, whereas GDF11 was a favorable predictor of ALS clinical score.
|
28170441 |
2017 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Correspondingly, TSA treatment was shown to decrease GDF11 expression and reverse CASMC dedifferentiation in the partial ligated carotid artery of mice.
|
30462553 |
2019 |
|
Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
This suggests an impaired GDF11 response contributing to anemia in AA patients.
|
30727851 |
2019 |
|
Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prior studies suggested that inhibition of growth differentiation factor 11 (GDF11) through soluble activin receptor type II (ActRII) ligand traps or neutralizing antibodies promotes erythroid precursor cell maturation and red blood cell formation in contexts of homeostasis and anemia.
|
31530563 |
2019 |
|
Anorexia Nervosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum GDF8, GDF11 and BMD were determined in 25 girls (12-16 years old) with AN and 31 healthy girls (12-16 years old).
|
30281844 |
2019 |
|
Aplastic Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GDF11 is increased in patients with aplastic anemia.
|
30727851 |
2019 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined.
|
30188752 |
2018 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We concluded that adeno-associated viruses-GDF11 and recombinant GDF11 protect against endothelial injury and reduce atherosclerosis in apolipoprotein E<sup>-/-</sup> mice, thus may be providing a novel approach to the treatment of atherosclerosis.
|
27502608 |
2016 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study presents GDF11 as a potential target for the treatment of inflammatory arthritis, including RA.-Li, W., Wang, W., Liu, L., Qu, R., Chen, X., Qiu, C., Li, J., Hayball, J., Liu, L., Chen, J., Wang, X., Pan, X., Zhao, Y. GDF11 antagonizes TNF-α-induced inflammation and protects against the development of inflammatory arthritis in mice.
|
30407878 |
2019 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We concluded that adeno-associated viruses-GDF11 and recombinant GDF11 protect against endothelial injury and reduce atherosclerosis in apolipoprotein E<sup>-/-</sup> mice, thus may be providing a novel approach to the treatment of atherosclerosis.
|
27502608 |
2016 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined.
|
30188752 |
2018 |
|
Atherosclerotic lesion
|
0.010 |
Biomarker
|
disease |
BEFREE |
GDF11 Protects against Endothelial Injury and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice.
|
27502608 |
2016 |
|
Atrophy of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
Systemic, high-dose GDF11 administration in adult mice led to renal failure, with accompanying kidney atrophy, interstitial fibrosis, epithelial-to-mesenchymal transition of renal tubular cells, and eventually death.
|
29731246 |
2018 |
|
Cachexia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Given this apparent contradiction in functionality, multiple independent labs sought to discern differences between the two factors and better elucidate age-related changes in circulating GDF11, with most failing to reproduce the initial finding of declining GDF11 levels, and, importantly, all subsequent studies examining the effects of GDF11 on skeletal muscle described an inhibitory effect on regeneration - and that higher doses induce skeletal muscle atrophy and cachexia.
|
31144559 |
2019 |
|
Cachexia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Here, we find that elevated GDF11 causes signs of cachexia in mice: reduced food intake, body weight, and muscle mass.
|
29425507 |
2018 |
|
Cachexia
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Although GDF11 treatment can reduce pathological cardiac hypertrophy and associated fibrosis while improving cardiac pump function in pressure overload, high doses of GDF11 cause severe cachexia and death.
|
30571461 |
2018 |
|
Cachexia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The TGF-β family ligands myostatin, GDF11, and activins are negative regulators of skeletal muscle mass, which have been reported to primarily signal via the ActRIIB receptor on skeletal muscle and thereby induce muscle wasting described as cachexia.
|
29109273 |
2017 |
|
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We found that GDF11 reduced arrhythmia severity and successfully attenuated myocardial infarction; GDF11 also increased cardiac function after I-R, enhanced HO-1 expression and decreased oxidative damage.
|
30900023 |
2019 |