Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Tumors were classified as high GDF11 expression (n=65) or low GDF11 expression (n=65).
|
17912435 |
2007 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
In conclusion, GDF11 has a tumor suppressor role in liver cancer, exerts its effects through Smad2/3 signaling and may serve as a novel tumor marker in liver cancer diagnosis.
|
29545874 |
2018 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Intracellular GDF11 retention adds to the concept of tumor-suppressor inactivation and reveals a cell-biological vulnerability for TNBCs lacking therapeutically actionable mutations.
|
29161592 |
2017 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion.
|
30890427 |
2019 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
These findings suggested that GDF11 acted as a tumor suppressor gene for pancreatic cancer.
|
30568460 |
2018 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We also demonstrate that CRC-associated human intestinal lymphatic endothelial cells regulate tumor cell growth via growth differentiation factor 11, a soluble matrisome component which in CRC patients was found to be associated with tumor progression.
|
30889293 |
2019 |
Cachexia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Given this apparent contradiction in functionality, multiple independent labs sought to discern differences between the two factors and better elucidate age-related changes in circulating GDF11, with most failing to reproduce the initial finding of declining GDF11 levels, and, importantly, all subsequent studies examining the effects of GDF11 on skeletal muscle described an inhibitory effect on regeneration - and that higher doses induce skeletal muscle atrophy and cachexia.
|
31144559 |
2019 |
Cachexia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Here, we find that elevated GDF11 causes signs of cachexia in mice: reduced food intake, body weight, and muscle mass.
|
29425507 |
2018 |
Cachexia
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Although GDF11 treatment can reduce pathological cardiac hypertrophy and associated fibrosis while improving cardiac pump function in pressure overload, high doses of GDF11 cause severe cachexia and death.
|
30571461 |
2018 |
Cachexia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The TGF-β family ligands myostatin, GDF11, and activins are negative regulators of skeletal muscle mass, which have been reported to primarily signal via the ActRIIB receptor on skeletal muscle and thereby induce muscle wasting described as cachexia.
|
29109273 |
2017 |
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined.
|
30188752 |
2018 |
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Daily intravenous treatment with GDF11-injection can rejuvenate respects of cognition and cerebrovascular changes in AD mice.
|
29480172 |
2018 |
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
We suggest that alterations of GDF11 and Tregs are involved in AD progression and that rejuvenation of the immune system is a potential therapeutic strategy in AD.
|
26317549 |
2015 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Since its discovery in 1999, studies have shown the involvement of GDF11 in normal physiological processes, such as embryonic development and erythropoiesis, as well as in the pathophysiology of aging, cardiovascular disease, diabetes mellitus, and cancer.
|
29113418 |
2017 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
This review is focused to present and analyze the recent findings in the emerging research field of GDF11 function in cancer and metabolism, and discusses the controversies surrounding the biology of this atypical growth factor.
|
31681577 |
2019 |
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001).
|
17912435 |
2007 |
Cardiovascular Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
Since its discovery in 1999, studies have shown the involvement of GDF11 in normal physiological processes, such as embryonic development and erythropoiesis, as well as in the pathophysiology of aging, cardiovascular disease, diabetes mellitus, and cancer.
|
29113418 |
2017 |
Cardiovascular Diseases
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The latest studies have shown that the level of circulating GDF 11 correlates with the outcomes of patients with cardiovascular diseases, cancer and uremia.
|
28223232 |
2017 |
Cardiovascular Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
Administration of GDF11 may be an efficacious therapy to protect against cardiovascular diseases in splenectomized patients.
|
27565745 |
2017 |
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We also demonstrate that CRC-associated human intestinal lymphatic endothelial cells regulate tumor cell growth via growth differentiation factor 11, a soluble matrisome component which in CRC patients was found to be associated with tumor progression.
|
30889293 |
2019 |
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11, a member of the transforming growth factor-β superfamily, has been reported to be involved in colorectal cancer.
|
29545874 |
2018 |
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Although multivariate analysis showed that GDF11 was not an independent prognostic factor, these findings suggest that GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer.
|
17912435 |
2007 |
Chronic Obstructive Airway Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The levels of plasma GDF11 in the COPD patients had significant positive correlations with the data of lung function.
|
29731621 |
2018 |
Chronic Obstructive Airway Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease.
|
28455454 |
2017 |
Chronic Obstructive Airway Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study suggests that GDF11 may be a novel target for the diagnosis and treatment of COPD.
|
29680737 |
2018 |