CDK8, cyclin dependent kinase 8, 1024

N. diseases: 82; N. variants: 3
Disease: Immune System Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021053
Disease: Immune System Diseases
Immune System Diseases 		0.010 AlteredExpression group BEFREE The results indicate that CDK8/19 is physiologically repressing Foxp3 expression in activated conventional T cells and that its pharmacological inhibition enables conversion of antigen-specific effector/memory T cells into Foxp3<sup>+</sup> T<sub>reg</sub> cells for the treatment of various immunological diseases. 31653719 2019