|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Given that obesity has been consistently identified as a major risk factor for uterine tumors, the most common malignancies of the female reproductive system, we use uterine tumors as a pathological context to survey the relevant literature and propose a novel hypothesis: chronic downregulation of the cyclin-dependent kinase 8 (CDK8) module, composed of CDK8 (or its paralog CDK19), Cyclin C, MED12 (or MED12L), and MED13 (or MED13L), by elevated insulin or insulin-like growth factor signaling in obese women may increase the chances to dysregulate the activities of transcription factors regulated by the CDK8 module, thereby increasing the risk of uterine tumors.
|
31520353 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cyclin C-Cdk8 kinase has been identified as both a tumor suppressor and an oncogene depending on the cell type.
|
31331961 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical expression of CDK8 and MED12 in leiomyosarcomas was correlated with the tumor grade, stage, and the presence of local recurrence or metastasis.
|
27389556 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, knockdown or inhibition of CDK8 had no significant effect on the growth of tumors implanted subcutaneously, intrasplenically, or orthotopically in the cecum.
|
30185549 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, CDK8 deletion increased expression of the lytic molecule perforin, which correlated with enhanced NK-cell cytotoxicity <i>in vitro</i> This translates into improved NK cell-mediated tumor surveillance <i>in vivo</i> in three independent models: B16F10 melanoma, <i>v-abl<sup>+</sup></i> lymphoma, and a slowly developing oncogene-driven leukemia.
|
29386186 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Strikingly, breast tumour suppression on Skp2 deficiency can be rescued by mH2A1 knockdown or CDK8 restoration using mouse tumour models.
|
25818643 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that the expression of CDK8 and its interactive genes has a profound impact on the response to adjuvant therapy in breast cancer in accordance with the role of CDK8 in chemotherapy-induced tumor-supporting paracrine activities.
|
26452386 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We observed that ectopic expression of CDK8 in KLE cells inhibited cell proliferation and potently blocked tumor growth in an in vivo mouse model.
|
23454913 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, the expression of CDK8 was correlated with the expression of β-catenin in both tumor and adjacent normal tissues (P < 0.05).
|
22104393 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The candidate genes located at deleted regions of chromosomes, such as FBLN2 (3p25.1), WNT7A (3p25), DLC1 (8p22), LZTS1 (8p22), CDKN2A (9p21), COL4A1 (13q34), CDK8 (13q12) and DCC (18q21.3), are found to be associated with the suppression of tumor.
|
20083228 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among 470 colorectal cancers identified in 2 prospective cohort studies, CDK8 expression was detected in 329 (70%) tumors by immunohistochemistry.
|
19790197 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression levels of cyclin-dependent kinase 8, phosphoinositide-3-kinase, interferon regulatory factor 3 and tubulin were significantly higher in the tumors of surviving patients with stage I lung cancer (p<0.01).
|
16969500 |
2006 |