QRT-PCR results revealed that microRNA-8073 expression in cancer tissue specimens of OC patients was significantly lower than that in corresponding normal tissues, and the difference was statistically significant.
QRT-PCR results revealed that microRNA-8073 expression in cancer tissue specimens of OC patients was significantly lower than that in corresponding normal tissues, and the difference was statistically significant.
QRT-PCR results revealed that microRNA-8073 expression in cancer tissue specimens of OC patients was significantly lower than that in corresponding normal tissues, and the difference was statistically significant.
QRT-PCR results revealed that microRNA-8073 expression in cancer tissue specimens of OC patients was significantly lower than that in corresponding normal tissues, and the difference was statistically significant.
QRT-PCR results revealed that microRNA-8073 expression in cancer tissue specimens of OC patients was significantly lower than that in corresponding normal tissues, and the difference was statistically significant.
We combined three miRNAs (miR-1246, miR-6756-5p, and miR-8073) into a single panel to generate an NNC model, which successfully detected BC with 97.1% accuracy in an independent validation cohort comprising 429 BC patients and 895 healthy controls.
Finally, the antiproliferative effects of miR-8073 were validated in vivo: the subcutaneous injection of a synthetic miR-8073 mimic suppressed colorectal tumor volume to 43% in tumor-bearing xenografted mice.
We combined three miRNAs (miR-1246, miR-6756-5p, and miR-8073) into a single panel to generate an NNC model, which successfully detected BC with 97.1% accuracy in an independent validation cohort comprising 429 BC patients and 895 healthy controls.