CDK9, cyclin dependent kinase 9, 1025

N. diseases: 204; N. variants: 1
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.030 Biomarker disease BEFREE Finally, TAK-243 was active against a number of in vivo myeloma models in association with activation of ER stress. 30737236 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.030 AlteredExpression disease BEFREE Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma. 29329658 2018
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.030 AlteredExpression disease BEFREE MM cell lines, primary MM specimens, and murine xenografts exhibited constitutive P-TEFb activation, manifested by high CTD (carboxy-terminal domain) S2 phosphorylation, associated with a) P-TEFb subunit up-regulation i.e., CDK9 (42 and 55 kDa isoforms) and cyclin T1; and b) marked CDK9 (42 kDa) T186 phosphorylation. 28938651 2017