SPRY1, sprouty RTK signaling antagonist 1, 10252

N. diseases: 63; N. variants: 1
Disease: Neointimal hyperplasia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4049446
Disease: Neointimal hyperplasia
Neointimal hyperplasia 		0.010 Biomarker disease BEFREE Our findings demonstrate that loss of Spry1 attenuates mitogen-induced VSMC proliferation, and thus injury-induced neointimal hyperplasia likely via insufficient activation of Akt signaling causing decreased cyclinD1 and increased p27<sup>Kip1</sup> and a subsequent decrease in Rb and cdc2 phosphorylation. 29105817 2018