|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 rs1056538;rs754504235;s754504235" genes_norm="7087;841">V301I (rs1056538) and NUMA1 A794G (rs3750913).
|
17293864 |
2007 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The method has a prediction accuracy of 77% on all mutants and 88% on breast cancer mutations affecting WAF1 promoter binding.
|
19558493 |
2009 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Although the exact biological mechanism remains to be explored, our findings suggest possible involvement of CDKN1A and CDKN1B variants in the etiology of breast cancer.
|
16804901 |
2006 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.
|
8663132 |
1996 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age >50 (OR = 2.21; 95 % CI 1.03-4.79).
|
24005533 |
2013 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways.
|
9499438 |
1998 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Endothelial cells grown alone and in TCM were immunostained for p21(WAF1/Cip1) and analyzed by RT-PCR Forty-four cases of breast cancer and forty-three cases of normal breast tissue were immunostained for p21(WAF1/Cip1).
|
16080520 |
2005 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model.
|
18695886 |
2008 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We hypothesized that inclusion of p21(WAF1), an indicator of biological function, into the p53 assay might improve the clinical value of p53 in breast cancer diagnosis.
|
16864977 |
2006 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells.
|
8959327 |
1996 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast cancer, but information about CDKN1C's role is limited.
|
18325103 |
2008 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We examined senescence induced by ionizing irradiation or ectopic overexpression of the stoichiometric cyclin-dependent kinase (CDK) inhibitor p21<sup>CIP/WAF1/SDI1</sup> in the human breast cancer cell line MCF7.
|
30987592 |
2019 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21(CIP1/WAF1), and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells.
|
11896290 |
2002 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The LKB1-mediated G(1) cell cycle arrest is caused by up-regulation of the expression of p21(WAF1/CIP1) in breast cancer MDA-MB-435 cells.
|
12114407 |
2002 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Heregulin-triggered Her-2/neu signaling enhances nuclear accumulation of p21WAF1/CIP1 and protects breast cancer cells from cisplatin-induced genotoxic damage.
|
15703820 |
2005 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We show that invasiveness of breast cancer cells is associated with growth arrest due to p21CIP1 upregulation.
|
22751124 |
2013 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We investigated the effect of the transfected p21 (Waf1) -p27 (Kip1) gene on centrosome duplication, cell proliferation, and apoptosis of MCF-7, a breast cancer cell line.
|
23338153 |
2014 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thus, our findings revealed resveratrol and curcumin synergistically caused apoptosis in cigarette smoke induced breast cancer cells through p2(Waf/Cip1) mediated inhibition of Hedgehog-Gli cascade.
|
26212257 |
2015 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Whereas multivariate analysis suggested associations between breast cancer and inheritance of Waf-1(ser31) in African-Americans (OR, 2.32; 95% CI = 0.66-5.60; n = 37 cases and 65 controls) and Latinas (OR, 2.22; 95% CI = 0.71-6.89; n = 30 cases and 75 controls), and inheritance of p53(1-2-1) in Caucasians (OR, 3.15; 95% CI = 1.14-8.89; n = 93 cases and 187 controls), we did not see an interaction between Waf-1(ser31) and p53(1-2-1).
|
11815410 |
2002 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here we investigated the role of p21Cip1 (p21), a member of the core cell cycle machinery, in transforming growth factor-beta (TGFβ)-mediated breast cancer cell migration and invasion.
|
22995475 |
2012 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We found that the novel tetrapeptide modulator causes moderate cytotoxicity to the human breast cancer cell (MCF-7 cell), induces the apoptotic death of MCF-7 cell, and activates the tumor suppressor proteins p53 and cyclin-dependent kinase inhibitor 1 (p21).
|
28558224 |
2018 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition, via qRT-PCR analysis of MDA-MB-231 cells, we observed that TNFα mediated the upregulation of gene transcripts associated with inflammation and senescence [IL-1-β, IL-6, IL-8, MCP-1, COX-2, p21(WAF1/CIP1)] and downregulated known tumor-promoting genes (collagen VI and MMP2).
|
23292149 |
2013 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that TA modulates EGF-R/Jak2/STAT1/3 and P38/STAT1/p21<sup>Waf1/Cip1</sup> pathways and induce G1-arrest and intrinsic apoptosis in breast carcinomas.
|
27862996 |
2017 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We have previously demonstrated that an inhibitor of HDAC, sodium butyrate (NaB), induces apoptosis of breast cancer cells in a P53-independent and P21(waf1)-dependent manner.
|
15265702 |
2004 |