|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 rs1056538;rs754504235;s754504235" genes_norm="7087;841">V301I (rs1056538) and NUMA1 A794G (rs3750913).
|
17293864 |
2007 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways.
|
9499438 |
1998 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the antiproliferative effect of silencing FLOT2 on breast cancer cells was associated with upregulation of cyclin-dependent kinase (CDK) inhibitors p21Cip1 and p27Kip1.
|
25738752 |
2015 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This agent is reported to increase the levels of p21WAF1/CIP1 in human breast cancer cell lines.
|
24568526 |
2014 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Endothelial cells grown alone and in TCM were immunostained for p21(WAF1/Cip1) and analyzed by RT-PCR Forty-four cases of breast cancer and forty-three cases of normal breast tissue were immunostained for p21(WAF1/Cip1).
|
16080520 |
2005 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Better to understand the mechanism of BMP-induced growth arrest we examined the effect of BMP-2 and mediators of BMP-2 action on cell proliferation and p21(Cip1) expression in breast cancer cell lines.
|
11786386 |
2002 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We previously found (M. V. Blagosklonny, et al., Cancer Res., 57: 320-325, 1997) that exposure of human SkBr3 breast cancer and LNCaP prostate cancer cells to 12-O-tetradecanoylphorbol-13-acetate (TPA) led to a growth arrest associated with the up-regulation of the cyclin-dependent kinase inhibitor p21(WAF1/cIP1) and the inhibition of c-Myc expression.
|
10319992 |
1999 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Moreover, low miR-143 and high GSK3-β, RAF1, paxillin, and p21CIP1 expression levels in a large cohort of patients with breast cancer were associated with worst outcome.
|
30755102 |
2019 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model.
|
18695886 |
2008 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We hypothesized that inclusion of p21(WAF1), an indicator of biological function, into the p53 assay might improve the clinical value of p53 in breast cancer diagnosis.
|
16864977 |
2006 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The method has a prediction accuracy of 77% on all mutants and 88% on breast cancer mutations affecting WAF1 promoter binding.
|
19558493 |
2009 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Various HDACi strongly inhibit breast cancer cell proliferation and ERalpha-negative (ER-) appear less sensitive than ERalpha-positive (ER+) cell lines. p21WAF1/CIP1 gene expression, in relation with ERalpha levels, could play a role in this differential response of breast cancer cells to hyperacetylating agents.
|
15313422 |
2004 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells.
|
8959327 |
1996 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast cancer, but information about CDKN1C's role is limited.
|
18325103 |
2008 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Although the exact biological mechanism remains to be explored, our findings suggest possible involvement of CDKN1A and CDKN1B variants in the etiology of breast cancer.
|
16804901 |
2006 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We examined senescence induced by ionizing irradiation or ectopic overexpression of the stoichiometric cyclin-dependent kinase (CDK) inhibitor p21<sup>CIP/WAF1/SDI1</sup> in the human breast cancer cell line MCF7.
|
30987592 |
2019 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Analysis of breast cancer samples reveals that a high LRH-1 level is inversely correlated with CDKN1A expression in breast cancer patients and is associated with poor prognosis.
|
25435372 |
2015 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21(CIP1/WAF1), and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells.
|
11896290 |
2002 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the pharmacological approaches to target p21<sup>Waf1/Cip1</sup> expression for therapy of breast cancer are clarified.
|
30255294 |
2019 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The LKB1-mediated G(1) cell cycle arrest is caused by up-regulation of the expression of p21(WAF1/CIP1) in breast cancer MDA-MB-435 cells.
|
12114407 |
2002 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Using human breast carcinoma MCF-7 cells as a model, we show here that PA-induced growth arrest is associated with enhanced expression of the cyclin-dependent kinase inhibitor p21Waf1/Cip1 and dephosphorylation of the retinoblastoma protein (pRB).
|
8959328 |
1996 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Heregulin-triggered Her-2/neu signaling enhances nuclear accumulation of p21WAF1/CIP1 and protects breast cancer cells from cisplatin-induced genotoxic damage.
|
15703820 |
2005 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We show that invasiveness of breast cancer cells is associated with growth arrest due to p21CIP1 upregulation.
|
22751124 |
2013 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, we found that silencing FLOT1 inhibited proliferation and tumorigenicity of breast cancer cells both in vitro and in vivo, which was further shown to be mechanistically associated with suppression of Akt activity, enhanced transcriptional activity of FOXO3a, upregulation of cyclin-dependent kinase inhibitor p21(Cip1) and p27(Kip1), and downregulation of the CDK regulator cyclin D1.
|
21447726 |
2011 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.
|
8663132 |
1996 |