|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the expression levels of stathmin and EF1α in relation to telomere length, telomere dysfunction-induced foci (TIF), γ-H2AX, and p21WAF1/CIP1 expression were assessed in specimens of hepatitis B virus (HBV)-related multistep hepatocarcinogenesis, including 13 liver cirrhosis specimens, 14 low-grade dysplastic nodules (DN), 17 high-grade DNs, and 14 hepatocellular carcinomas (HCC).
|
24885363 |
2014 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A number of interactions between the two carcinogens may be responsible for this action, including integration of hepatitis B virus x gene and its consequences, as well as interference with nucleotide excision repair, activation of p21waf1/cip1, generation of DNA mutations, and altered methylation of genes.
|
24078988 |
2013 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of another senescence regulator, p21(waf1), however, were not affected by HBx under our senescence-inducing conditions.
|
19656618 |
2010 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study shows that telomere shortening, chromosomal instability, and inactivation of p21(WAF1/CIP1) checkpoint function occur in low-grade dysplastic nodules as well as in high-grade dysplastic nodules, and their cooperation is considered to be critical for malignant transformation during hepatitis B virus associated-multistep hepatocarcinogenesis.
|
19465904 |
2009 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, our aim was to investigate the relationships between P21 protein expression and hepatocyte proliferation, hepatitis B virus replication, and hepatitis activity.
|
16252182 |
2005 |
|
Hepatitis B
|
0.100 |
PosttranslationalModification
|
disease |
LHGDN |
Subcellular localization and transcriptional repressor activity of HBx on p21(WAF1/Cip1) promoter is regulated by ERK-mediated phosphorylation.
|
15184045 |
2004 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed that p53 over-expression is a reliable marker for mutational modulation of p53 function. p53 was negatively correlated with p21/WAF1 in hepatitis B virus-related HCC (p=0.024, r=-0.432).
|
15201954 |
2004 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene.
|
15107488 |
2004 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
P21WAF1/CIP1 messenger RNA expression in hepatitis B, C virus-infected human hepatocellular carcinoma tissues.
|
11391590 |
2001 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells.
|
10918595 |
2000 |