Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results demonstrate that downregulation of microRNA-95-3p suppresses cell growth of osteosarcoma via CDKN1A/p21 expression.
|
29115549 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results revealed that SsCEI 4 triggered a proliferative arrest specifically in osteosarcoma U2OS cells via downregulation of the APEH-proteasome system, with the accumulation of the typical hallmarks of proteasome: NF-κB, p21(Waf1), and polyubiquitinylated proteins.
|
27669226 |
2016 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest.
|
26034982 |
2015 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mechanistic investigations revealed that MEF2D silencing triggered G2-M arrest in osteosarcoma cells by suppressing RPRM and CDKN1A. miR-144 was found to suppress the expression of MEF2D in osteosarcoma cells.
|
25814384 |
2015 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show here that CLP induces the expression of p21(WAF1/CIP1) with growth arrest in p53-mutated human osteosarcoma MG63 cells.
|
17786325 |
2007 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that both early-passage Foxm1(-)(/)(-) mouse embryonic fibroblasts (MEFs) and human osteosarcoma U2OS cells depleted of FoxM1 protein by small interfering RNA fail to grow in culture due to a mitotic block and accumulate nuclear levels of cyclin-dependent kinase inhibitor (CDKI) proteins p21(Cip1) and p27(Kip1).
|
16314512 |
2005 |
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is uncommon for the p21WAF1/CIP1 gene mutation to occur in human osteosarcoma.
|
15198903 |
2004 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, stable transfection of p21CIP1/WAF1 and p16INK4a genes in two osteosarcoma cell lines (KHOS and U2-OS cells) showed that p21CIP1/WAF1 was able to repress the immortal phenotype in both cell lines, whereas temporary over-expression of p16INK4a reversibly inhibited the cell growth.
|
11695244 |
2002 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
In addition, stable transfection of p21CIP1/WAF1 and p16INK4a genes in two osteosarcoma cell lines (KHOS and U2-OS cells) showed that p21CIP1/WAF1 was able to repress the immortal phenotype in both cell lines, whereas temporary over-expression of p16INK4a reversibly inhibited the cell growth.
|
11695244 |
2002 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2.
|
10571205 |
1999 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, no WAF1 expression was induced by cold shock in p53-deficient human osteosarcoma Saos-2 cells.
|
9525749 |
1998 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the effects of antisense cyclin G1, in comparison with antisense cyclin D1 (CYCD1) and enforced expression of the universal cyclin-dependent kinase inhibitor p21WAF1/CIP1 on the proliferation of human MG-63 osteosarcoma cells.
|
7585620 |
1995 |