Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previously, we demonstrated that magnolol, a hydroxylated biphenyl compound isolated from the bark of Magnolia officinalis, at low concentrations (3-10 μM) exerted an antiproliferation effect in colon cancer, hepatoma, and glioblastoma (U373) cell lines through upregulation of the p21/Cip1 protein.
|
23448150 |
2013 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we demonstrate a role for synemin in enhancing glioblastoma cell proliferation and clonogenic survival, as synemin RNA interference decreased both behaviors by inducing G1 arrest along with Rb hypophosphorylation and increased protein levels of the G1/S inhibitors p21(Cip1) and p27(Kip1).
|
22337773 |
2012 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Induction of p21(WAF1/Cip1) mediated by silencing of HDAC4 arrested cancer cell growth in vitro and inhibited tumor growth in an in vivo human glioblastoma model.
|
18850004 |
2009 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.
|
18316600 |
2008 |
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the combination of p16 and p21(CIP1) (p21-S154A) peptides dramatically suppressed the growth of glioblastoma line Gli36DeltaEGFR, which carries a missense mutation in p53, by >97% after 120 h. Significantly, our murine brain tumor model for dual-peptide delivery showed a substantial average survival enhancement (P < 0.0001) for peptide-treated mice.
|
18566217 |
2008 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lithium increases expression of p21(WAF/Cip1) and survivin in human glioblastoma cells.
|
17103031 |
2007 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromatin immunoprecipitation revealed that P-c-Jun is bound to the proximal part of p21WAF1/Cip1 promoter in CsA-treated glioblastoma cells.
|
17321721 |
2007 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of the glioblastoma cell cycle by type I IFNs occurs at both the G1 and S phases and correlates with the upregulation of p21(WAF1/CIP1).
|
11100820 |
2000 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A colony assay for radiosensitivity and Western blot analysis of WAF1 were applied to two human glioblastoma cell lines, A-172 bearing wild-type p53 (wtp53) and T98G bearing mutated p53 (mp53).
|
10757313 |
2000 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Attenuation of WAF1/Cip1 expression by an antisense adenovirus expression vector sensitizes glioblastoma cells to apoptosis induced by chemotherapeutic agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin.
|
9918219 |
1999 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that WAF1 expression is cold shock-inducible in human glioblastoma cells, and that this induction may be due to signal transduction mediated by p53 in response to non-genotoxic stress, cold shock.
|
9525749 |
1998 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We established a doxycycline-inducible WAF1/Cip1 expression system in two glioblastoma cell lines and examined the role of WAF1/Cip1 in their response to the chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and cis-diamminedichloroplatinum (cisplatin), in an isogeneic background.
|
9537261 |
1998 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study reports the successful growth suppression of a rat glioblastoma model (RT-2) both in vitro and in vivo by the insertion of p21(WAF1/CIP1), a negative cell cycle regulatory gene, into the tumor cells.
|
9144534 |
1997 |
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the increased WAF1 protein and mRNA levels that were due to acidic treatment returned to normal levels upon the return of the cells to neutral conditions, 6 h after the cells had been cultured in acidic conditions for 6 or 12 h. These findings suggest that WAF1 gene activation is inducible by acidic conditions in human glioblastoma cells, which is probably due to activation of the p53-dependent signal transduction pathway.
|
9307270 |
1997 |
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the expression of WAF1/Cip1 protein in 14 glioblastoma cell lines and found that WAF1/Cip1 expression was detectable in many of the cell lines, even when mutant p53 was present.
|
8547219 |
1995 |