|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
ChIP assays indicated that the binding efficiency of p53 to the p21/WAF1 gene promoter was much lower in miR-17 transfected OCCs than in OCCs transfected with a mutated miR-17.
|
25510663 |
2015 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53.
|
23603558 |
2013 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
p21 WAF1 is involved in interferon-β-induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression in ovarian cancer.
|
20814747 |
2010 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of FOXG1 contributes to TGF-beta resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer.
|
19755996 |
2009 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.
|
17606716 |
2007 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In this study, we focused on serous ovarian cancer, which is the most prevalent histological type, and performed immunohistochemical analysis to examine the expression of p21(WAF1/CIP1) and p53 in 43 cases of serous-type EOC sourced from a single University Hospital: 14 stage I, 4 stage II, 21 stage III, and 4 stage IV.
|
16012716 |
2005 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
LHGDN |
Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer.
|
15297421 |
2004 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
LHGDN |
We introduced the wild-type p16(INK4a), p21(WAF1/Cip-1), and p53 genes into the ovarian cancer cell lines SK-OV-3 (p16(INK4a) and p53 null) and OVCA-420 (p16(INK4a) and p53 wild-type) by adenoviral transfection.
|
11733969 |
2001 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The seriousness of ovarian cancer, which is related to the observed link between recurrency and cell cycle control defect, prompted us to explore the effect of ectopic expression of the cdk inhibitor p21(cip1/waf1) on ovarian carcinoma chemosensitivity.
|
11078909 |
2000 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
p21WAF1/CIP1 protein expression in primary ovarian cancer.
|
11078810 |
2000 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conducted a retrospective immunohistochemical evaluation of the prognostic significance of the expression of p53 and the related proteins Bax, Bcl-2, growth arrest and DNA damage (Gadd45), murine double minute 2 (Mdm2) and p21(WAF1/CIP1) in chemonaive tumours taken from 66 patients with ovarian cancer.
|
11094305 |
2000 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A protective role for common p21WAF1/Cip1 polymorphisms in human ovarian cancer.
|
10375603 |
1999 |