|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Moreover, the result of protein-protein interaction network showed that CDKN1A gene was related to the prognosis of HCC.
|
30585632 |
2019 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CONCLUSIONS We found that JUN, EGR1, MYC, and CDKN1A might be used as diagnostic and therapeutic molecular biomarkers and broaden our understanding of the molecular mechanisms of HCC.
|
29795057 |
2018 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21<sup>Waf1/Cip1</sup> and p19<sup>INK4d</sup> upregulation in hepatocellular carcinoma.
|
29484736 |
2018 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Inhibition of hepatocellular carcinoma tumorigenesis by curcumin may be associated with CDKN1A and CTGF.
|
29408622 |
2018 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, MDIG had effects on the level of p21(CIP1/WAF1) via H3K9me3 expression in HCC.
|
28471446 |
2017 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC.
|
29383172 |
2017 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
ARID1A upregulates its downstream target CDKN1A and suppresses HCC cell proliferation and migration through inhibiting MVIH.
|
28716731 |
2017 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To elucidate new regulatory mechanisms for heptocarcinogenesis, we investigated the regulation of p21, a cyclin-dependent kinase (CDK) inhibitor encoded by CDKN1A, in HCC.
|
27698442 |
2016 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We found that uc.338 promotes HCC cell proliferation and induces cell cycle progression through association with BMI1. uc.338 also modulated the transcription of CDKN1A.
|
27154519 |
2016 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Even though p21 generally functions as a tumor suppressor, paradoxically many cancers, including HCC, are known to express elevated levels of p21 that correlate with poor prognosis.
|
26725321 |
2016 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The results revealed that 1,25(OH)2D3 treatment reduced the expression of HDAC2 and increased the expression of p21(WAF1/Cip1), in a dose-dependent manner, resulting in the reduction of HCC growth.
|
26676829 |
2016 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We concluded that miR-93 stimulated cell proliferation, migration, and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC.
|
25633810 |
2015 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that knockdown of the farnesoid X receptor (FXR) effectively suppresses the proliferation of human hepatocellular carcinoma cell lines HepG2 and HLE accompanied by elevated expression of cyclin-dependent kinase (CDK) inhibitor p16/INK4a and p21/Cip1 proteins.
|
26165647 |
2015 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the expression levels of stathmin and EF1α in relation to telomere length, telomere dysfunction-induced foci (TIF), γ-H2AX, and p21WAF1/CIP1 expression were assessed in specimens of hepatitis B virus (HBV)-related multistep hepatocarcinogenesis, including 13 liver cirrhosis specimens, 14 low-grade dysplastic nodules (DN), 17 high-grade DNs, and 14 hepatocellular carcinomas (HCC).
|
24885363 |
2014 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study provides important evidence for inhibition of hepatocellular carcinoma (HCC) growth by 15-PGDH through the 15-keto-prostaglandin E2 (15-keto-PGE2)/peroxisome proliferator-activated receptor-γ (PPARγ)/p21(WAF1/Cip1) signaling pathway.
|
23542179 |
2014 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrated that miR-105 could deactivated the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway by downregulating insulin receptor substrate-1, 3-phosphoinositide-dependent protein kinase-1 and AKT1 directly, resulting in increasing cyclin-dependent kinase inhibitors 1A and 1B (p21(Cip1) and p27(Kip1)) and decreasing cyclin D1 expression in HCC.
|
25280563 |
2014 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings suggest that UCN-01 induces hepatoma cell growth inhibition by regulating the p53/p21(waf1) and CHK2/CDC25 pathways.
|
23537372 |
2013 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Targeted p21WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells.
|
22909100 |
2012 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Anti-cancer effects of p21WAF1/CIP1 transcriptional activation induced by dsRNAs in human hepatocellular carcinoma cell lines.
|
21666704 |
2011 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
MicroRNA-423 promotes cell growth and regulates G(1)/S transition by targeting p21Cip1/Waf1 in hepatocellular carcinoma.
|
21890460 |
2011 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, proliferation index of 60 human HCCs was inversely correlated with protein levels but not with mRNA levels of P21(WAF1), P27(KIP1), P57(KIP2) and P130, indicating a control of human HCC proliferation by posttranslational modifications of cell cycle regulators.
|
19533683 |
2010 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The p21(WAF1/CIP1) labeling index was significantly higher in cirrhosis than in normal livers (P=0.024) and markedly decreased in low-grade dysplastic nodules, high-grade dysplastic nodules, and hepatocellular carcinomas compared with cirrhosis (P<0.05).
|
19465904 |
2009 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
G2-phase arrest through p21(WAF1 / Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells.
|
19414386 |
2009 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In primary human hepatocellular carcinomas (HCC), loss of NORE1A expression is frequent and correlates tightly with loss of p21(CIP1) expression.
|
19435914 |
2009 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that overexpression of integrin beta1 subunit imposed a growth inhibitory effect on the hepatocellular carcinoma cell line SMMC-7721 through transcriptional activation of p21(WAF1/CIP1) gene.
|
17211849 |
2007 |