|
Carcinoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study.
|
23409082 |
2013 |
|
Carcinoma
|
0.200 |
Biomarker
|
group |
BEFREE |
To investigate the role of cell cycle regulators in the pathogenesis and progression of human gastric cancer, the expression of cyclin D1, A, B1, p16(INK4a), p21(CPI1), p27(KIP1), p53, and pRb was investigated in 482 gastric carcinomas using immunohistochemistry in terms of histologic type, tumor invasion, size, location, and metastatic behavior.
|
20334896 |
2010 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways.
|
19855998 |
2009 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
On the other hand, both Se forms decreased the expression of cyclin D1 and increased levels of P27Kip1 and c-Jun NH2-terminal kinase activation in a majority of the mammary carcinomas.
|
19276161 |
2009 |
|
Carcinoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Indeed, genetic ablation of the p27(Kip1) or Rb genes accentuated Tag-induced tumorigenesis, with loss of Rb in particular broadly enhancing multiple parameters of tumorigenesis including the frequency and growth rates of premalignant lesions, of nascent solid tumors, and of invasive carcinomas.
|
16007165 |
2005 |
|
Carcinoma
|
0.200 |
Biomarker
|
group |
BEFREE |
A progressive significant increase in the levels of 8-OHdG and in the percentage of mean positive cells was observed from L-SIL (2.2%) to H-SIL (12.5%) to invasive carcinomas (25.2%). p27Kip1 and 8-OHdG expression displayed a significant inverse relationship.
|
14984940 |
2004 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Distinct altered patterns of p27Kip1 protein expression are found in a variety of human carcinomas, and p27Kip1 expression levels usually correlate directly with disease-free survival.
|
11042700 |
2000 |
|
Carcinoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Although the short follow-up time (2-3 years) of the current series of patients does not allow the performance of survival analyses, the correlation of beta(1C) expression with tumor size, grade, and proliferative fraction and its alleged role as an upstream regulator of p27(kip1) make this integrin variant a likely novel prognostic parameter for invasive carcinomas of the breast.
|
10623664 |
2000 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Although genetic changes of p27/kip1 are extremely rare, in many human carcinomas p27 levels are reduced, correlate with histological malignancy, and are associated with poor prognosis.
|
10603039 |
1999 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Contrary to that, high levels of p27Kip1 are associated with poor overall survival in invasive cervical carcinomas of clinical stage IB.
|
9891436 |
1999 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Parathyroid hyperplasia, adenomas, and carcinomas: differential expression of p27Kip1 protein.
|
10078919 |
1999 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
This study was undertaken to identify potential abnormalities of p27(Kip1) and cyclin D1 expression in extrahepatic bile duct carcinomas and to assess the prognostic significance of p27(Kip1) and cyclin D1 levels for patients with this disease.
|
10534337 |
1999 |
|
Carcinoma
|
0.200 |
Biomarker
|
group |
BEFREE |
In this study, we evaluated the prognostic value of p27Kip1 in a series of 96 superficial (pTa-1) human bladder carcinomas.
|
10397272 |
1999 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Lack of detectable expression of p27kip1 cyclin dependent kinase inhibitor has previously been correlated with high degree of malignancy in human breast, colorectal, gastric and small cell lung carcinomas.
|
10597239 |
1999 |
|
Carcinoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
In contrast to BPH, prostate carcinomas were found to contain abundant p27KIP1 mRNA but either high or low to undetectable levels of p27 protein.
|
9731735 |
1998 |
|
Carcinoma
|
0.200 |
Biomarker
|
group |
HPO |
|
|
|