|
Leukemia, Myelocytic, Acute
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In intermediate-risk AML in which multiple gene expression markers were tested by NanoString, IL2RA significantly correlated with ID1 (p = 0.006), FLT3 (p = 0.007), CDKN1B (p = 0.033) and ERG (p = 0.030) expressions.
|
31171000 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
ETV6 and CDKN1B had reduced expression levels in CK-AML patients with deletion in 12p13 as compared to CK-AML without deletion in 12p13, while the other genes (BCL2L14, LRP6, DUSP16 and GPRC5D) located within the minimal deleted region in 12p13 had very low or missing expression in CK-AML irrespective of their copy number status.
|
25213837 |
2014 |
|
Leukemia, Myelocytic, Acute
|
0.080 |
Biomarker
|
disease |
BEFREE |
In this study, the expression of these markers and of EVI1 and CDKN1B was determined using oligonucleotide microarrays in 286 AML comprising all cytogenetic groups.
|
22072540 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.080 |
Biomarker
|
disease |
BEFREE |
CDKN1B is an interesting candidate gene as a potential biomarker for prognostication in acute myeloid leukemia.
|
21422114 |
2011 |
|
Leukemia, Myelocytic, Acute
|
0.080 |
Biomarker
|
disease |
BEFREE |
A statistically significant correlation between expression of VEGF and p27(Kip1) was observed in bone marrows from 42 patients with acute myeloid leukemia (P<0.001).
|
18987662 |
2009 |
|
Leukemia, Myelocytic, Acute
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
Therefore, we analysed 9 haematopoietic cell lines, 67 myelodysplastic syndrome (MDS) and 26 acute myeloid leukaemia (AML) cases as well as 11 controls. p 57(KIP 2) hypermethylation was found in 4/9 cell lines, but methylation of p21(CIP 1) and p27(KIP 1) was infrequent.
|
15936816 |
2005 |
|
Leukemia, Myelocytic, Acute
|
0.080 |
PosttranslationalModification
|
disease |
LHGDN |
Both the disease-free survival and overall survival are significantly shorter in AML cases with high cytoplasmic to nuclear ratio of p27Kip1 localization compared with the cases with low cytoplasmic to nuclear ratio (P = 0.0353, P = 0.0023, respectively).
|
15289327 |
2004 |
|
Leukemia, Myelocytic, Acute
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
One of sixty cytogenetically aberrant myeloid malignancies, an AML with a complex karyotype including del(5q) and del(20q), showed a hemizygous interstitial deletion of the ETV6 and CDKN1B loci.
|
9171997 |
1997 |